SynthesisWorld journal of surgical oncology2018
Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies.
Synthesis in World journal of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07272317 (PSMA-PET/MRI-Ultrasound Multimodal Fusion Navigation for Da Vinci Robot-Assisted Radical Prostatectomy), which is not on this map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PSMA-PET/MRI-Ultrasound Multimodal Fusion Navigation for Da Vinci Robot-Assisted Radical Prostatectomy: A Randomized Controlled Trial
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) during robot-assisted radical prostatectomy: a systematic review and meta-analysis of comparative studies.Prostate cancer and prostatic diseases · 2025Pooled it
- Pooled it
- The impact of surgical margin status on prostate cancer-specific mortality after radical prostatectomy: a systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020Pooled it
- Predictive Factors for Positive Surgical Margins in Patients With Prostate Cancer After Radical Prostatectomy: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Label-free navigation system for grading prostate tumour malignancy in situ via tissue pH and prostate-specific antigen activity.Nature biomedical engineering · 2026Article
- Prognostic significance of positive margin-informed tumor status in esophageal squamous cell carcinoma using next-generation sequencing.The oncologist · 2026Article
- Development and internal validation of a biparametric MRI-based nomogram for predicting extraprostatic extension in patients undergoing robot-assisted radical prostatectomy.Journal of robotic surgery · 2026Article
- Impact of positive surgical margins on biochemical recurrence and metastases after radical prostatectomy.BJU international · 2026Article
- Machine learning-based prognostic model integrating preoperative HALP score and lactate dehydrogenase for predicting postoperative recurrence of prostate cancer.World journal of surgical oncology · 2026Article
- Relationship between the status of positive surgical margins and biochemical recurrence: developing a risk stratification model for biochemical recurrence following radical prostatectomy.Journal of robotic surgery · 2026Article
- Perineural Invasion in Radical Prostatectomy Specimens and Its Association with Biochemical Recurrence and Survival in Prostate Cancer: A Systematic Review and Meta-analysis.European urology open science · 2026Review
- Exploring the use of preoperative MRI for assessing the anatomical location of positive surgical margin at robot-assisted radical prostatectomy (RARP).World journal of urology · 2026Article
- Predicting Biochemical Recurrence After Robot-Assisted Prostatectomy with Interpretable Machine Learning Model.Journal of clinical medicine · 2025Article
- Enhancing nerve sparing in robotic prostate surgery: the impact of NeuroSAFE on fascia preservation score.Translational andrology and urology · 2025Article
- Genetic alterations of prostate cancer: in localized and metastatic prostate cancer.BMC urology · 2025Article
- Risk analysis of adverse pathological changes in cT2cN0M0 prostate cancer after robot-assisted radical prostatectomy: Results from a population-based study.Asian journal of urology · 2025Article
- Analysis of risk factors for positive margins in robot-assisted laparoscopic radical prostatectomy with Retzius-sparing (RS-RARP).World journal of surgical oncology · 2025Article
- Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study.Scientific reports · 2025Article
- Prognostic value and predictive model construction for patients undergoing laparoscopic radical prostatectomy based on the preoperative NPL-IRS score and prognostic nutritional index.Frontiers in oncology · 2025Article
- Interpretable machine learning models based on multi-dimensional fusion data for predicting positive surgical margins in robot-assisted radical prostatectomy: a retrospective study.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAlthough numerous studies have shown that positive surgical margin (PSM) is linked to biochemical recurrence (BCR) in prostate cancer (PCa), the research results have been inconsistent. This study aimed to explore the association between PSM and BCR in patients with PCa following radical prostatectomy (RP). MATERIALS AND
methodsIn accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), PubMed, EMBASE and Wan Fang databases were searched for eligible studies from inception to November 2017. The Newcastle-Ottawa Scale was used to assess the risk of bias of the included studies. Meta-analysis was performed by using Stata 12.0. Combined hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated using random-effects or fixed-effects models.
resultsUltimately, 41 retrospective cohort studies of high quality that met the eligibility criteria, comprising 37,928 patients (94-3294 per study), were included in this meta-analysis. The results showed that PSM was associated with higher BCR risk in both univariate analysis (pooled HR = 1.56; 95% CI 1.46, 1.66; p < 0.001) and multivariate analysis (pooled HR = 1.35; 95% CI 1.27, 1.43; p < 0.001). Moreover, no potential publication bias was observed among the included studies in univariate analysis (p-Begg = 0.971) and multivariate analysis (p-Begg = 0.401).
conclusionsOur meta-analysis demonstrated that PSM is associated with a higher risk of BCR in PCa following RP and could serve as an independent prognostic factor in patients with PCa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.