Evidence map›Paper›PMID 29970066›Full record

ArticleBMC pulmonary medicine2018

Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study.

Lusmaia Damaceno Camargo Costa, Paulo Augusto Moreira Camargos, Paul L P Brand, Fabíola Souza Fiaccadori, Menira Borges de Lima Dias E Souza, Divina das Dôres de Paula Cardoso, Ítalo de Araújo Castro, Ruth Minamisava, Paulo Sérgio Sucasas da Costa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Prevalence of respiratory viruses in stable and acute asthma: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Viruses in bronchiectasis.ERJ open research · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lusmaia Damaceno Camargo CostaPediatric Pulmonology Unit, University Hospital, Federal University of Goiás, Primeira Avenida, S/N. Setor Leste Universitária, Goiânia, CEP: 746050-20, Brazil. lusmaiapneumoped@gmail.com.
Paulo Augusto Moreira CamargosPediatric Pulmonology Unit, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Paul L P BrandPrincess Amalia Children's Centre, Isala Hospital, Zwolle, and UMCG Postgraduate School of Medicine, University Medical Centre and University of Groningen, Groningen, the Netherlands.
Fabíola Souza FiaccadoriHuman Virology Department, Public Health and Tropical Pathology Institute, Federal University of Goiás, Goiânia, Brazil.
Menira Borges de Lima Dias E SouzaHuman Virology Department, Public Health and Tropical Pathology Institute, Federal University of Goiás, Goiânia, Brazil.
Divina das Dôres de Paula CardosoHuman Virology Department, Public Health and Tropical Pathology Institute, Federal University of Goiás, Goiânia, Brazil.
Ítalo de Araújo CastroHuman Virology Department, Public Health and Tropical Pathology Institute, Federal University of Goiás, Goiânia, Brazil.
Ruth MinamisavaFaculty of Nursing, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Paulo Sérgio Sucasas da CostaPediatric Pulmonology Unit, University Hospital, Federal University of Goiás, Primeira Avenida, S/N. Setor Leste Universitária, Goiânia, CEP: 746050-20, Brazil.
Universidade Federal de Goiás · BRUniversidade Federal de Minas Gerais · BRUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMultiple factors are involved in asthma exacerbations, including environmental exposure and viral infections. We aimed to assess the association between severe asthma exacerbations, acute respiratory viral infections and other potential risk factors.

methodsAsthmatic children aged 4-14 years were enrolled for a period of 12 months and divided into two groups: those with exacerbated asthma (group 1) and non-exacerbated asthma (group 2). Clinical data were obtained and nasopharyngeal samples were collected through nasopharyngeal aspirate or swab and analysed via indirect fluorescent immunoassays to detect influenza A and B viruses, parainfluenza 1-3, adenovirus and respiratory syncytial virus. Rhinovirus was detected via molecular assays. Potential risk factors for asthma exacerbation were identified in univariate and multivariate analyses.

resultsIn 153 children (group 1: 92; group 2: 61), median age 7 and 8 years, respectively, the rate of virus detection was 87.7%. There was no difference between groups regarding the frequency of virus detection (p = 0.68); however, group 1 showed a lower frequency (19.2%) of inhaled corticosteroid use (91.4%, p < 0.01) and evidence of inadequate disease control. In the multivariate analysis, the occurrence of three or more visits to the emergency room in the past 12 months (IRR = 1.40; p = 0.04) and nonadherence to inhaled corticosteroid (IRR = 4.87; p < 0.01) were the only factors associated with exacerbation.

conclusionOur results suggest an association between asthma exacerbations, poor disease control and nonadherence to asthma medication, suggesting that viruses may not be the only culprits for asthma exacerbations in this population.

Indexed as

AdolescentAdrenal Cortex HormonesAsthmaBrazilChildChild, PreschoolCross-Sectional StudiesDisease ProgressionFemaleHumansMaleMedication AdherenceMultivariate AnalysisRegression AnalysisRespiratory SystemRespiratory Tract InfectionsAdrenal Cortex HormonesAsthmaChildExacerbationsVirus

Identifiers

PMID29970066
PMCPMC6029112
OpenAlexW2811389256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.