Evidence map›Paper›PMID 29970006›Full record

ArticleBMC cardiovascular disorders2018

A case report of myocarditis combined with hepatitis caused by herpes simplex virus.

Tetsuya Yamamoto, Tsuneaki Kenzaka, Masanori Matsumoto, Ryo Nishio, Satoru Kawasaki, Hozuka Akita

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Severe acute herpes virus type 2 primo-infection and its association with anti-type 1 interferon autoantibodies.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Article
  4. Review
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  8. Article
  9. Article
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  11. Article
  12. Advances in the relationship between coronavirus infection and cardiovascular diseases.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tetsuya YamamotoDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
Tsuneaki KenzakaDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan. smile.kenzaka@jichi.ac.jp.ORCID 0000-0002-3120-6605
Masanori MatsumotoDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
Ryo NishioDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
Satoru KawasakiDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
Hozuka AkitaDepartment of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
Ebara Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundViral myocarditis presents with various symptoms, including fatal arrhythmia and cardiogenic shock, and may develop into chronic myocarditis and dilated cardiomyopathy in some patients. We report a case of viral myocarditis and hepatitis caused by herpes simplex virus. CASE PRESENTATION: A 20-year-old woman was admitted to our hospital with fever, fatigue, and anorexia. The initial investigation showed elevated liver enzyme levels and elevated creatine phosphokinase, and computed tomography showed diffuse swelling and internal heterogeneous image in the liver. These findings were consistent with acute hepatitis; therefore, we performed a liver biopsy, which showed parenchymal necrosis and lymphocytic infiltration. The night that the liver biopsy was performed, blood pressure gradually decreased and revealed cardiogenic shock. Electrocardiography showed diffuse ST-segment elevation, and echocardiography showed a dilated, spherical ventricle with reduced systolic function and pericardial effusion. An endomyocardial biopsy revealed lymphocyte infiltration of the myocardium, confirming acute myocarditis. After a few days, tests for immunoglobin M and immunoglobin G antibodies against herpes simplex virus were positive.

conclusionsWe presented a rare case of myocarditis combined with hepatitis that was caused by herpes simplex virus. Acute myocarditis can occur concurrently with hepatitis, pancreatitis, nephritis, and encephalitis; thus, determining the presence of other infectious lesions is necessary to provide appropriate treatment for the patient.

Indexed as

BiopsyEchocardiographyElectrocardiographyFemaleHepatitis, Viral, HumanHerpes SimplexHumansMyocarditisSimplexvirusTomography, X-Ray ComputedYoung AdultCase reportHepatitisHerpes simplex virusMyocarditis

Identifiers

PMID29970006
PMCPMC6029390
OpenAlexW2809927538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.