ArticleBMC gastroenterology2018
Children with cyclic vomiting syndrome: phenotypes, disease burden and mitochondrial DNA analysis.
Article in BMC gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Cyclic Vomiting Syndrome in Children.Frontiers in neurology · 2020Pooled it
- Mitochondrial haplogroup A2 is associated with increased COVID-19 mortality in an admixed Brazilian population.Scientific reports · 2025Article
- Disease characteristics and long-term outcomes of cyclic vomiting syndrome in Singaporean children.World journal of gastrointestinal pharmacology and therapeutics · 2025Article
- Symptom Patterns in Adults With Cyclic Vomiting Syndrome: A 6-Month Prospective Observational Study.Neurogastroenterology and motility · 2025Observational
- Article
- Productivity Loss and Indirect Burden of Cyclic Vomiting Syndrome in the United States.Gastro hep advances · 2022Article
- Association of Mitochondrial DNA Polymorphisms With Pediatric-Onset Cyclic Vomiting Syndrome.Frontiers in pediatrics · 2022Article
- The childhood migraine syndrome.Nature reviews. Neurology · 2021Review
- Highlighting the importance of early diagnosis of cyclic vomiting syndrome in adults: A case report.Medicine · 2019Article
- Cyclic Vomiting Syndrome in Children and Adults: What Is New in 2018?Current gastroenterology reports · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclic vomiting syndrome (CVS) is characterized by repeated, stereotypical vomiting episodes. It is possibly associated with mitochondrial DNA (mtDNA) variants. We examined the phenotype, disease burden, treatment and performed mtDNA analysis in pediatric CVS.
methodsThis retrospective study included 42 children with CVS in a tertiary care center. Information regarding medical history, clinical features, laboratory tests, and treatment were collected. mtDNA sequencing was performed among 13 patients.
resultsMean age of onset among patients was 4.0±3.4 years, and mean age at diagnosis was 6.7±4.2 years. CVS episodes in onset and features were stereotypic. Recognizable prodromes were reported in 54.8% patients. Neuroimaging showed previously unknown intracranial abnormalities. Gastrointestinal infection was found in four patients. Mean duration of hospitalization was 7.0±2.4 days, and mean hospitalization cost was 10,891 RMB. Sequencing showed that 4/13 patients had C16519T mtDNA polymorphism, and 2/13 patients had G3010A mtDNA polymorphism.
conclusionsCyclic vomiting syndrome is a disabling disorder, which causes huge disease burdens to the patients and their families. Early clinical suspicion and prompt diagnosis are crucial. mtDNA polymorphisms were found in some patients, but they were not significantly associated with pediatric CVS.
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