ArticleJournal of feline medicine and surgery2018
Bioengineered surgical repair of a chronic oronasal fistula in a cat using autologous platelet-rich fibrin and bone marrow with a tailored 3D printed implant.
Article in Journal of feline medicine and surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Recent Advances in Bone Tissue Engineering: Enhancing the Potential of Mesenchymal Stem Cells for Regenerative Therapies.Current issues in molecular biology · 2025Review
- Translational Clinical Research: Use of Allogeneic Platelet-Rich Fibrin (PRF) for Wound Regeneration in Two Small-Sized Dogs.Animals : an open access journal from MDPI · 2025Article
- Management of canine wounds using platelet-rich fibrin (PRF) biomaterial. A case series report.Veterinary medicine and science · 2024Article
- Recasting the gold standard - part I of II: delineating healthcare options across a continuum of care.Journal of feline medicine and surgery · 2023Review
- Autologous platelet-rich fibrin promotes wound healing in cats.Frontiers in veterinary science · 2023Article
- microRNAs Are Abundant and Stable in Platelet-Rich Fibrin and Other Autologous Blood Products of Canines.International journal of molecular sciences · 2023Article
- In Vitro Assessment of Lyophilized Advanced Platelet-Rich Fibrin from Dogs in Promotion of Growth Factor Release and Wound Healing.Veterinary sciences · 2022Article
- Evaluation of a Standardized Protocol for Plasma Rich in Growth Factors Obtention in Cats: A Prospective Study.Frontiers in veterinary science · 2022Article
- Canine-Origin Platelet-Rich Fibrin as an Effective Biomaterial for Wound Healing in Domestic Cats: A Preliminary Study.Veterinary sciences · 2021Article
- The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering.Polymers · 2021Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical summary: A tissue engineering approach was used to aid the surgical repair of a chronic oronasal fistula (ONF) in a 13-year-old cat. A three-dimensional (3D) printed mesh, tailored to the size and shape of the ONF, was created to support a soft tissue flap used to close the defect; and also to provide a matrix for mesenchymal stromal cells present in bone marrow aspirate and bioactive cytokines and growth factors present in platelet-rich fibrin harvested from the patient. A CT scan at day 75 after surgery revealed the formation of new tissue in the defect and the healing process was complete at follow-up 6 months after surgery. Relevance and novel information: Complications are frequently reported following surgical repair of ONFs and include dehiscence of the palatal suture line, flap necrosis due to damage to the greater palatine artery and maxillary osteomyelitis, mainly due to chronic infection and bone lysis. The case described here demonstrates how input from a multidisciplinary team and the use of a biomaterial, processed by sophisticated technologies, can create a precision regenerative medicine strategy adapted to the patient's clinical needs; this provided a novel therapeutic solution for an otherwise hard to treat clinical problem.
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Registered trials
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