ArticleThe journal of allergy and clinical immunology. In practice2019
Drug-Induced Anaphylaxis Documented in Electronic Health Records.
Article in The journal of allergy and clinical immunology. In practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- The cost-effectiveness of penicillin allergy testing: Evidence and gaps from a systematic review.PloS one · 2025Pooled it
- The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021: A Systematic Review.Immunology and allergy clinics of North America · 2022Pooled it
- Pooled it
- Antibiotics for the urgent management of symptomatic irreversible pulpitis, symptomatic apical periodontitis, and localized acute apical abscess: Systematic review and meta-analysis-a report of the American Dental Association.Journal of the American Dental Association (1939) · 2019Pooled it
- Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association.Journal of the American Dental Association (1939) · 2019Guideline
- A protocol proposal for safe dental anaesthesia in paediatric patients with allergic backgrounds: insights from a case series of allergic patients.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Discrepancies and Quality of Medication Allergy Documentation Between Primary Care and Hospital Information Systems: A Retrospective Cohort Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Drug-induced anaphylaxis: Molecular pathophysiology, diagnosis, and management.Asia Pacific allergy · 2026Article
- Successful management of protracted anaphylaxis-induced severe acute respiratory distress syndrome masquerading as non-ST elevation myocardial infarction: a rare case report.BMC cardiovascular disorders · 2026Article
- Cephalosporin allergy: R1 side-chain and penicillin cross-reactivity patterns in an Australian cohort.The journal of allergy and clinical immunology. Global · 2026Article
- Gender and Allergy: Mechanisms, Clinical Phenotypes, and Therapeutic Response-A Position Paper from the Società Italiana di Allergologia, Asma ed Immunologia Clinica (SIAAIC).International journal of molecular sciences · 2025Review
- Antibiotic Prescribing for Cellulitis in the Absence of Penicillin-Cephalosporin Cross-Reactivity Alerts: A Retrospective Study.Pharmacology research & perspectives · 2025Article
- Severe drug-associated anaphylaxis: a complementary descriptive analyses of registry cases and spontaneous reports.European journal of clinical pharmacology · 2025Article
- The incidence of hypersensitivity to non-steroid anti-inflammatory drugs in the group of patients with rheumatoid musculoskeletal disorders: the cross-sectional study.Rheumatology international · 2025Article
- Labeled NSAID hypersensitivity and the risk of opioid prescribing; an observational study.Frontiers in allergy · 2025Article
- Is the Anamnesis Enough to De-Label Patients with Reported Beta-Lactam Allergy?Journal of clinical medicine · 2024Article
- [A multicenter clinical study on the incidence and influencing factors of cephalosporin-induced anaphylaxis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Serum metabolomics analysis reveals potential biomarkers of penicillins-induced fatal anaphylactic shock in rats.Scientific reports · 2024Article
- Cephalosporin Allergy: Updates on Diagnostic Testing.Current allergy and asthma reports · 2024Review
- Anaphylaxis in a country where Asia and Europe meet: Evaluation according to World Allergy Organization (WAO) and European Academy of Allergy and Clinical Immunology (EAACI) diagnostic criteria.The World Allergy Organization journal · 2024Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundAlthough drugs represent a common cause of anaphylaxis, few large studies of drug-induced anaphylaxis have been performed.
objectiveTo describe the epidemiology and validity of reported drug-induced anaphylaxis in the electronic health records (EHRs) of a large United States health care system.
methodsUsing EHR drug allergy data from 1995 to 2013, we determined the population prevalence of anaphylaxis including anaphylaxis prevalence over time, and the most commonly implicated drugs/drug classes reported to cause anaphylaxis. Patient risk factors for drug-induced anaphylaxis were assessed using a logistic regression model. Serum tryptase and allergist visits were used to assess the validity and follow-up of EHR-reported anaphylaxis.
resultsAmong 1,756,481 patients, 19,836 (1.1%) reported drug-induced anaphylaxis; penicillins (45.9 per 10,000), sulfonamide antibiotics (15.1 per 10,000), and nonsteroidal anti-inflammatory drugs (NSAIDs) (13.0 per 10,000) were most commonly implicated. Patients with white race (odds ratio [OR] 2.38, 95% CI 2.27-2.49), female sex (OR 2.20, 95% CI 2.13-2.28), systemic mastocytosis (OR 4.60, 95% CI 2.66-7.94), Sjögren's syndrome (OR 1.94, 95% CI 1.47-2.56), and asthma (OR 1.50, 95% CI 1.43-1.59) had an increased odds of drug-induced anaphylaxis. Serum tryptase was performed in 135 (<1%) anaphylaxis cases and 1,587 patients (8.0%) saw an allergist for follow-up.
conclusionsEHR-reported anaphylaxis occurred in approximately 1% of patients, most commonly from penicillins, sulfonamide antibiotics, and NSAIDs. Females, whites, and patients with mastocytosis, Sjögren's syndrome, and asthma had increased odds of reporting drug-induced anaphylaxis. The low observed frequency of tryptase testing and specialist evaluation emphasize the importance of educating providers on anaphylaxis management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.