ArticlePloS one2018
Chemo-mapping and biochemical-modulatory and antioxidant/prooxidant effect of Galium verum extract during acute restraint and dark stress in female rats.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Anticancer Effects of Galium aparine L Extract: Dose-Dependent Cytotoxicity in HNO210 Human Laryngeal Carcinoma Cells.The Journal of craniofacial surgery · 2026Article
- Bioactive Phytocompound Profiling and the Evaluation of Antioxidant, Antihyperglycemic, and Antimicrobial Activities of Medicinal Plants from Serbian Traditional Medicine.Molecules (Basel, Switzerland) · 2026Article
- The Therapeutic Potential ofInternational journal of molecular sciences · 2025Article
- Electrochemical Investigations ofMaterials (Basel, Switzerland) · 2025Article
- A Review of Phytochemical and Pharmacological Studies onMolecules (Basel, Switzerland) · 2025Review
- Investigating the Therapeutic Property of Galium verum L. (GV) for MSG induced Audiogenic Epilepsy (AEs) and Neuroprotection throughCentral nervous system agents in medicinal chemistry · 2025Article
- Recent Updates Regarding the Antiproliferative Activity ofLife (Basel, Switzerland) · 2024Article
- Phytochemical and Nutraceutical Screening of Ethanol and Ethyl Acetate Phases of RomanianMolecules (Basel, Switzerland) · 2023Article
- Antioxidants fromPlants (Basel, Switzerland) · 2022Article
- The Phytochemical Analysis ofMolecules (Basel, Switzerland) · 2021Article
- Article
- One‒pot green synthesized protein‒based silver nanocluster as prooxidant biosensor.Turkish journal of chemistry · 2021Article
- Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Remarkable rutin-rich Hypericum capitatum extract exhibits anti-inflammatory effects on turpentine oil-induced inflammation in rats.BMC complementary and alternative medicine · 2019Article
- Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Galium verum is a well-known medicinal plant which is used in various pathologies. G. verum extracts are characterized here using chromatography, where among the rich pool of phenolic acids of flavonoids two known anti-stress modulators, chlorogenic acid and rutin are identified in high quantities. Additionally, the extracts are characterized using a series of in vitro assays (EPR, DPPH, TPC and TEAC). Considering the chemical findings, the potential beneficial effects of the G. verum extract are explored here in a living organism exposed to stress induced oxidative damages. Thus, the biochemical-modulatory and antioxidant roles of two doses of G. verum extract are examined in animals exposed to acute restraint and dark stress (S). The animals were divided in groups [control, S, SG1 (exposed to 25 mg G. verum extract), SG2 (50 mg extract)]. Increased levels of lipid peroxidation (TBARS from 4.43 to 8.06 nmol/mL), corticosterone from 0.43 to 1.96 μg/dL and epinephrine from 44.43 to 126.7 μg/mL, as well as decreased antioxidant enzymes activities (SOD/CAT) were observed in the S group. The G. verum extract afforded a near-normal equilibrium within the biochemical parameters of animals exposed to RS, by reducing oxidative damage (TBARS at a 3.73 nmol/mL; CS at 0.90 μg/dL; EP at 63.72 μg/mL) and by restoring the antioxidant balance.
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