ArticlePLoS computational biology2018
Post-Turing tissue pattern formation: Advent of mechanochemistry.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mechanochemical patterning localizes the organizer of a luminal epithelium.Science advances · 2025Article
- Stochastic morphological swings inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Hydrocortisone treatment as a tool to study conjunctival placode induction.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Mechanical characterization of regenerating Hydra tissue spheres.Biophysical journal · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- Three-dimensional chiral morphodynamics of chemomechanical active shells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pulsatile contractions and pattern formation in excitable actomyosin cortex.PLoS computational biology · 2022Article
- Pattern formation features might explain homoplasy: fertile surfaces in higher fungi as an example.Theory in biosciences = Theorie in den Biowissenschaften · 2022Review
- Patterning, From Conifers to Consciousness: Turing's Theory and Order From Fluctuations.Frontiers in cell and developmental biology · 2022Review
- Mathematical models of nitrogen-fixing cell patterns in filamentous cyanobacteria.Frontiers in cell and developmental biology · 2022Review
- Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.PLoS computational biology · 2021Article
- Reaction-diffusion models for morphological patterning of hESCs.Journal of mathematical biology · 2021Article
- Modeling mechanochemical pattern formation in elastic sheets of biological matter.The European physical journal. E, Soft matter · 2021Article
- Mechanical Models of Pattern and Form in Biological Tissues: The Role of Stress-Strain Constitutive Equations.Bulletin of mathematical biology · 2021Article
- Roadmap for the multiscale coupling of biochemical and mechanical signals during development.Physical biology · 2021Review
- Review
- Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.PLoS biology · 2019Article
- Article
- Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback.Nature communications · 2019Article
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4 authors.
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Abstract
Chemical and mechanical pattern formation is fundamental during embryogenesis and tissue development. Yet, the underlying molecular and cellular mechanisms are still elusive in many cases. Most current theories assume that tissue development is driven by chemical processes: either as a sequence of chemical patterns each depending on the previous one, or by patterns spontaneously arising from specific chemical interactions (such as "Turing-patterns"). Within both theories, mechanical patterns are usually regarded as passive by-products of chemical pre-patters. However, several experiments question these theories, and an increasing number of studies shows that tissue mechanics can actively influence chemical patterns during development. In this study, we thus focus on the interplay between chemical and mechanical processes during tissue development. On one hand, based on recent experimental data, we develop new mechanochemical simulation models of evolving tissues, in which the full 3D representation of the tissue appears to be critical for obtaining a realistic mechanochemical behaviour. The presented modelling approach is flexible and numerically studied using state of the art finite element methods. Thus, it may serve as a basis to combine simulations with new experimental methods in tissue development. On the other hand, we apply the developed approach and demonstrate that even simple interactions between tissue mechanics and chemistry spontaneously lead to robust and complex mechanochemical patterns. Especially, we demonstrate that the main contradictions arising in the framework of purely chemical theories are naturally and automatically resolved using the mechanochemical patterning theory.
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