Integrating loop gain into the understanding of obstructive sleep apnoea mechanisms.

Luu V Pham, Alan R Schwartz, Vsevolod Y Polotsky

Abstract readComment

In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Quantification of ventilatory control in sleep apnea: from physiological insight to computable loop gain.Sleep · 2026
Review
Role of Nasal Surgery in Adult Obstructive Sleep Apnea: A Systematic Review.Sleep science (Sao Paulo, Brazil) · 2024
Review
Pharmacological and Genetic Blockade ofHypertension (Dallas, Tex. : 1979) · 2021
Article
Newly identified sleep-wake and circadian circuits as potential therapeutic targets.Sleep · 2019
Review
Neural Circuitry Underlying Waking Up to Hypercapnia.Frontiers in neuroscience · 2019
Review
Silencing of Hypoglossal Motoneurons Leads to Sleep Disordered Breathing in Lean Mice.Frontiers in neurology · 2018
Article

4 · The record

Corrections and comments

Comment on
Breath-holding as a means to estimate the loop gain contribution to obstructive sleep apnoea.2018

5 · Who and what money

Authors and funding

3 authors.

Luu V PhamDivision of Pulmonary Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0002-1944-6315

Alan R SchwartzDivision of Pulmonary Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.

Vsevolod Y PolotskyDivision of Pulmonary Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.ORCID 0000-0002-2951-7535

Funding

Melanocortin 4 signaling in the carotid body in obesityR01HL133100 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Vsevolod Y Polotsky, Wan-yee Tang · 2016 to 2026

$7.1M

Treatment of Sleep Apnea by Targeting Leptin SignalingR01HL128970 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MENDELOWITZ, DAVID, POLOTSKY, VSEVOLOD Y · 2015 to 2023

$5.4M

Chemogenetic approach to treat Obstructive Sleep ApneaR01HL138932 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POLOTSKY, VSEVOLOD Y · 2017 to 2020

$2.4M

NHLBI NIH HHS R01 HL128970NHLBI NIH HHS R01 HL133100NHLBI NIH HHS R01 HL138932

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Sleep Apnea, ObstructiveContinuous Positive Airway PressureHumanscollapsibilityloop gainneuromuscular activationobstructive sleep apneapathogenesisPcritventilatory

Identifiers

PMID29968907

DOI10.1113/JP276590

PMCPMC6117553

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.