Evidence map›Paper›PMID 29968808›Full record

ArticleScientific reports2018

Synergy of Physico-chemical and Biological Experiments for Developing a Cyclooxygenase-2 Inhibitor.

Palwinder Singh, Jagroop Kaur, Harpreet Kaur, Anudeep Kaur, Rajbir Bhatti

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Palwinder SinghDepartment of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, 143005, India. palwinder_singh_2000@yahoo.com.ORCID 0000-0003-2332-5257
Jagroop KaurDepartment of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, 143005, India.
Harpreet KaurDepartment of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, 143005, India.
Anudeep KaurDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.
Rajbir BhattiDepartment of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, 143005, India.ORCID 0000-0002-5761-7074
Guru Nanak Dev University · IN

Funding

DST | Science and Engineering Research Board (SERB) EMR/2015/001548
6 · The paper itself

Abstract

The physiological consequences of COX-2 overexpression in the development of cancer, diabetes and neurodegenerative diseases have made this enzyme a promising therapeutic target. Herein, COX-2 active site was analyzed and new molecules were designed. We identified a highly potent molecule (S)-3a with IC

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsDrug DesignDrug DiscoveryHumansInflammationMalePainRatsRats, WistarStructure-Activity RelationshipAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 Inhibitors

Identifiers

PMID29968808
PMCPMC6030096
OpenAlexW2810232209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.