ArticleScientific reports2018
Adolescent social stress increases anxiety-like behavior and ethanol consumption in adult male and female C57BL/6J mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Alcohol or Stress Exposure During Late Adolescence Impairs Risk Assessment Later in Life, Disrupting the Ethological Structure of Behavior in Mice.Alcohol, clinical & experimental research · 2026Article
- Adolescent stress exposure induces persistent, sex-specific cognitive deficits.Neurobiology of learning and memory · 2025Article
- The Impacts of Binge Drinking and Hangover on the Social Brain: An Integrative Narrative Review.Biomedicines · 2025Review
- A Novel Mouse Home Cage Lickometer System Reveals Sex- and Housing-Based Influences on Alcohol Drinking.eNeuro · 2024Article
- Distinct roles of the left and right prelimbic cortices in the modulation of ethanol consumption in male mice under acute and chronic social defeat stress.Psychopharmacology · 2024Article
- A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking.bioRxiv : the preprint server for biology · 2024Article
- Alcohol and stress exposure across the lifespan are key risk factors for Alzheimer's Disease and cognitive decline.Neurobiology of stress · 2024Article
- Interstrain differences in adolescent fear conditioning after acute alcohol exposure.Brain research bulletin · 2023Article
- Article
- The impact of adolescent stress on nicotine use and affective disorders in rodent models.The European journal of neuroscience · 2022Review
- Chronic, but not sub-chronic, stress increases binge-like alcohol consumption in male and female c57BL6 mice.Frontiers in behavioral neuroscience · 2022Article
- FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.Neuroscience and biobehavioral reviews · 2022Review
- Social isolation-related depression accelerates ethanol intake via microglia-derived neuroinflammation.Science advances · 2021Article
- Cardinal role of the environment in stress induced changes across life stages and generations.Neuroscience and biobehavioral reviews · 2021Review
- Adolescent Stress Reduces Adult Morphine-Induced Behavioral Sensitization in C57BL/6J Mice.Frontiers in behavioral neuroscience · 2021Article
- Noradrenergic tone mediates marble burying behavior after chronic stress and ethanol.Psychopharmacology · 2020Article
- Ethanol consumption and sedation are altered in mice lacking the glycine receptor α2 subunit.British journal of pharmacology · 2020Article
- Chronic repeated predatory stress induces resistance to quinine adulteration of ethanol in male mice.Behavioural brain research · 2020Article
- Adolescent forced swim stress increases social anxiety-like behaviors and alters kappa opioid receptor function in the basolateral amygdala of male rats.Progress in neuro-psychopharmacology & biological psychiatry · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Exposure to social stress is an important risk factor for comorbid affective disorders and problem alcohol use. To better understand mechanisms involved in social stress-induced affective disorder and alcohol use co-morbidity, we studied the effects of adolescent social stress on anxiety- and depression-like behaviors and binge-like ethanol consumption. Male and female C57BL/6J mice were exposed to chronic variable social stress (CVSS) or control conditions throughout adolescence (postnatal days, PND, 25-59) and then tested for anxiety-like behavior in the elevated plus maze and a novel open field environment, or depression-like behavior using the forced swim test on PND 64-66. Mice were then tested for binge-like ethanol consumption using the Drinking-in-the-Dark model. Male and female mice exposed to adolescent CVSS had increased adult anxiety-like behavior and increased locomotor adaptation to a novel environment. Further, CVSS mice consumed significantly more ethanol, but not saccharin, than controls. Despite group differences in both anxiety-like behavior and ethanol consumption, there was no relationship between these outcomes within individual mice. These data suggest that exposure to adolescent social stress is an important risk factor for later alcohol use and affective behaviors, but that social stress does not necessarily dictate co-morbidity of these outcomes.
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Registered trials
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