ArticleScientific reports2018
High Magnesium Corrosion Rate has an Effect on Osteoclast and Mesenchymal Stem Cell Role During Bone Remodelling.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
- Current status and future prospects of biodegradable magnesium-based implants developed for orthopaedic applications.Journal of orthopaedic translation · 2026Review
- Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.Journal of Zhejiang University. Science. B · 2025Review
- Biodegradability and biocompatibility test of Magnesium Carbonate apatite composite implants fabricated by extrusion technique on Sprague Dawley Rats.Scientific reports · 2025Article
- Strategies for promoting neurovascularization in bone regeneration.Military Medical Research · 2025Review
- Bioabsorbable magnesium-based bulk metallic glass composite (BMGC) for improved medial opening wedge high tibial osteotomy in knee osteoarthritis.Journal of orthopaedic translation · 2025Article
- Research progress on osteoclast regulation by biodegradable magnesium and its mechanism.Regenerative biomaterials · 2025Review
- Novel Magnesium- and Silver-Loaded Dressing Promotes Tissue Regeneration in Cutaneous Wounds.International journal of molecular sciences · 2024Article
- Application and Perspectives: Magnesium Materials in Bone Regeneration.ACS biomaterials science & engineering · 2024Review
- Challenges and Pitfalls of Research Designs Involving Magnesium-Based Biomaterials: An Overview.International journal of molecular sciences · 2024Review
- Peri-articular elbow fracture fixations with magnesium implants and a review of current literature: A case series.World journal of orthopedics · 2024Article
- The Effect of Mixed Polymethylmethacrylate and Hydroxyapatite on Viability of Stem Cell from Human Exfoliated Deciduous Teeth and Osteoblast.European journal of dentistry · 2024Article
- The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery.Biomaterials research · 2024Review
- Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting.Current osteoporosis reports · 2023Review
- Long-Term Temporospatial Complementary Relationship between Degradation and Bone Regeneration of Mg-Al Alloy.ACS applied bio materials · 2023Article
- Bioactivity Features of a Zn-1%Mg-0.1%Dy Alloy Strengthened by Equal-Channel Angular Pressing.Biomimetics (Basel, Switzerland) · 2023Article
- Transcriptome analysis of hydrogen inhibits osteoclastogenesis of mouse bone marrow mononuclear cells.Experimental and therapeutic medicine · 2023Article
- Sustained release of magnesium and zinc ions synergistically accelerates wound healing.Bioactive materials · 2023Article
- Magnesium (Mg2 +), Strontium (Sr2 +), and Zinc (Zn2 +) Co-substituted Bone Cements Based on Nano-hydroxyapatite/Monetite for Bone Regeneration.Biological trace element research · 2023Article
- Corrosion Behavior and Biocompatibility of Hot-Extruded Mg-Zn-Ga-(Y) Biodegradable Alloys.Journal of functional biomaterials · 2022Article
- The osteogenetic activities of mesenchymal stem cells in response to Mg2+ ions and inflammatory cytokines: a numerical approach using fuzzy logic controllers.PLoS computational biology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
The aim of this study was to gain an understanding on the collective cellular effects of magnesium (Mg) corrosion products on the behaviour of cells responsible for bone formation and remodelling. The response of mesenchymal stem cells (MSCs) and osteoclast cells to both soluble (Mg ions) and insoluble (granule) corrosion products were recapitulated in vitro by controlling the concentration of the corrosion products. Clearance of corrosion granules by MSCs was also inspected by TEM analysis at sub-cellular level. The effect of Mg corrosion products varied depending on the state of differentiation of cells, concentration and length of exposure. The presence of the corrosion products significantly altered the cells' metabolic and proliferative activities, which further affected cell fusion/differentiation. While cells tolerated higher than physiological range of Mg concentration (16 mM), concentrations below 10 mM were beneficial for cell growth. Furthermore, MSCs were shown to contribute to the clearance of intercellular corrosion granules, whilst high concentrations of corrosion products negatively impacted on osteoclast progenitor cell number and mature osteoclast cell function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.