Evidence map›Paper›PMID 29968776›Full record

ArticleScientific reports2018

Relationship between interleukin (IL)-6 and brain morphology in drug-naïve, first-episode major depressive disorder using surface-based morphometry.

Shingo Kakeda, Keita Watanabe, Asuka Katsuki, Koichiro Sugimoto, Natsuki Igata, Issei Ueda, Ryohei Igata, Osamu Abe, Reiji Yoshimura, Yukunori Korogi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 8 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 8 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  7. Meta-analysis of cortical thickness abnormalities in medication-free patients with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
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  16. Ribosomal DNA and Neurological Disorders.Current molecular medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Shingo KakedaDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan. kakeda@med.uoeh-u.ac.jp.ORCID 0000-0002-0521-9728
Keita WatanabeDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Asuka KatsukiDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
Koichiro SugimotoDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Natsuki IgataDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Issei UedaDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ryohei IgataDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
Osamu AbeDepartment of Radiology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yukunori KorogiDepartment of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing body of evidence to support the involvement of proinflammatory cytokines in the pathophysiology of depression; however, no previous studies have examined the relationship between cytokines and the brain morphology of patients with major depressive disorder (MDD). We therefore evaluated the relationship between serum cytokine levels and cortical thinning during the first depressive episode in drug-naïve patients with MDD. We measured the serum cytokine levels (IL-1β, IL-6, IFN-γ, and TNFα), and whole-brain cortical thickness and hippocampal subfield volumes on brain magnetic resonance imaging (MRI) using surface-based morphometry in 40 patients with MDD and 47 healthy volunteers (controls). Only the serum IL-6 level was significantly higher in patients with MDD than in controls. The prefrontal cortex (PFC) thickness was significantly reduced in patients with MDD, and showed a significant inverse correlation with the serum IL-6 level. Although high serum IL-6 levels were correlated with reduced left subiculum and right CA1, CA3, CA4, GC-DG, subiculum, and whole hippocampus volumes, the presence or absence of MDD had no effect on the volume of any hippocampal subfields. Our results suggest that IL-6 may play a key role in the morphological changes in the PFC during the early stage of MDD.

Indexed as

AdultBrainCytokinesFemaleHumansInterferon-gammaInterleukin-1betaInterleukin-6Magnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedTumor Necrosis Factor-alphaYoung AdultCytokinesInterferon-gammaInterleukin-1betaInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID29968776
PMCPMC6030126
OpenAlexW2811426992

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.