ArticleScientific reports2018
Estimation of chimpanzee age based on DNA methylation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Review
- Epigenetic Signatures of Ageing in Asian Elephants Revealed by Reduced Representation Bisulphite Sequencing.Evolutionary applications · 2026Article
- Less-invasive age estimation using hair based on DNA methylation in brown bears.Scientific reports · 2025Article
- Article
- Noninvasive, epigenetic age estimation in an elasmobranch, the cownose ray (Rhinoptera bonasus).Scientific reports · 2024Article
- Approaching the mystery of aging by the epigenetic clock.Primates; journal of primatology · 2024Article
- Epigenetic aging studies of pair bonding in prairie voles.Scientific reports · 2024Article
- An epigenetic toolbox for conservation biologists.Evolutionary applications · 2024Article
- Article
- Getting the chronological age out of DNA: using insights of age-dependent DNA methylation for forensic DNA applications.Genes & genomics · 2023Review
- Behavioral Welfare Research for the Management of Sanctuary Chimpanzees (Animals : an open access journal from MDPI · 2023Article
- Article
- Novel feature selection methods for construction of accurate epigenetic clocks.PLoS computational biology · 2022Article
- Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.Communications biology · 2021Article
- Age estimation using methylation-sensitive high-resolution melting (MS-HRM) in both healthy felines and those with chronic kidney disease.Scientific reports · 2021Article
- Epigenetic age prediction.Aging cell · 2021 · on this mapReview
- Ageing European lobsters (Evolutionary applications · 2021Article
- An epigenetic clock to estimate the age of living beluga whales.Evolutionary applications · 2021Article
- Article
- Age-associated epigenetic change in chimpanzees and humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
In wild animal conservation, knowing the age of an individual animal is extremely beneficial. However, estimating the age is difficult for many species. Recently, epigenetics-based methods of estimating age have been reported. These studies were predominantly on humans with few reports on other animals, especially wild animals. In the present study, a chimpanzee (Pan troglodytes) age prediction model was developed based on the ELOVL2, CCDC102B, and ZNF423 genes that may also have application in human age prediction. Pyrosequencing was used to measure methylation in 20 chimpanzee blood samples and correlation between age and methylation status was calculated. Age and methylation of sites in ELOVL2 and CCDC102B were significantly correlated and an age prediction model was created using these genes. In the regression equation using only ELOVL2, the highest correlation coefficient was 0.741, with a mean absolute deviation (MAD) of 5.41, compared with the combination of ELOVL2 and CCDC102B, where the highest correlation coefficient was 0.742 and the MAD was 5.41. Although larger MADs were observed in chimpanzees than in humans based on these genes, the results indicate the feasibility of estimating chimpanzee age using DNA methylation, and can have implications in understanding the ecology of chimpanzees and chimpanzee conservation.
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