ArticleScientific reports2018
Changes in intestinal gene expression and microbiota composition during late pregnancy are mouse strain dependent.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05754645 (The PROMOTE Study, a Pilot), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The PROMOTE Study, a Pilot: The Characterization of the Microbiome in Pregnancy and Prediction of Pregnancy Outcomes
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- A Review of Gut Microbiota Dynamics: From Healthy Gestation to Gestational Diabetes in Human and Mouse Models.Biomedicines · 2026Review
- Characterization of the gut microbiome of wildFrontiers in microbiomes · 2026Article
- Immune Dysregulation at the Maternal-Fetal Interface Exacerbates Adverse Pregnancy Outcomes in an Inflammatory Arthritis Murine Model.Biomedicines · 2025Article
- Article
- Immunological reference intervals in pregnancy: longitudinal analysis of adaptive lymphocyte subsets.Frontiers in immunology · 2025Article
- Host-gut microbiota interactions during pregnancy.Evolution, medicine, and public health · 2024Review
- The Effect of Antibiotics Treatment on the Maternal Immune Response and Gut Microbiome in Pregnant and Non-Pregnant Mice.Nutrients · 2023Article
- Pregnancy imparts distinct systemic adaptive immune function.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022Article
- Microbiota of the Pregnant Mouse: Characterization of the Bacterial Communities in the Oral Cavity, Lung, Intestine, and Vagina through Culture and DNA Sequencing.Microbiology spectrum · 2022Article
- Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.Gastroenterology · 2022Article
- The intestine and the microbiota in maternal glucose homeostasis during pregnancy.The Journal of endocrinology · 2022Review
- Gut and lung microbiome profiles in pregnant mice.Frontiers in microbiology · 2022Article
- Effect of Housing Condition and Diet on the Gut Microbiota of Weanling Immunocompromised Mice.Comparative medicine · 2021Article
- Relationship between gut microbiota and host-metabolism: Emphasis on hormones related to reproductive function.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2021Review
- Variation of Gut Microbiome in Free-Ranging Female Tibetan Macaques (Animals : an open access journal from MDPI · 2020Article
- A comprehensive analysis of the microbiota composition and gene expression in colorectal cancer.BMC microbiology · 2020Article
- Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics.Experimental & molecular medicine · 2020Review
- Reproductive hormones mediate changes in the gut microbiome during pregnancy and lactation in Phayre's leaf monkeys.Scientific reports · 2020Article
- Microbiota Induced Changes in the Immune Response in Pregnant Mice.Frontiers in immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hormones and placental factors are thought to underlie the maternal immunological changes during pregnancy. However, as several intestinal microbiota are linked to immune modulations, we hypothesized that the intestinal microbiota are altered during pregnancy in favor of species associated with pregnancy associated immune modulations. We studied the fecal microbiota composition (MITchip) and intestinal and peripheral immune cells (microarray and flow cytometry) in pregnant and non-pregnant C57BL/6 and BALB/c mice. Pregnancy influenced intestinal microbiota diversity and composition, however in a mouse strain dependent way. Pregnant BALB/c mice had, among others, a relative higher abundance of Lactobacillus paracasei et rel., Roseburia intestinalis et rel. and Eubacterium hallii et rel., as compared to non-pregnant BALB/c mice, while the microbiota composition in B6 mice hardly changed during pregnancy. Additionally, intestinal immunological pathways were changed during pregnancy, however again in a mouse strain dependent way. Correlations between various bacteria and immunological genes were observed. Our data do support a role for the microbiome in changing immune responses in pregnancy. However, other factors are also involved, such as for instance changes in SCFA or changes in sensitivity to bacteria, since although immunological changes are observed in B6 mice, hardly any changes in microbiota were found in this strain. Follow up studies are needed to study the exact relationship between these parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.