ArticleEnvironmental health perspectives2018
Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects.
Article in Environmental health perspectives, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toxic Substances Control Act (TSCA) Implementation: How the Amended Law Has Failed to Protect Vulnerable Populations from Toxic Chemicals in the United States.Environmental science & technology · 2022Pooled it
- Integration of mechanistic and repeat dose toxicity data in the derivation of an oral reference dose for HFPO-DA.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Risk assessment of trihalomethanes in drinking water with seasonal variation considerations.Scientific reports · 2026Article
- Characterizing variability and uncertainty for parameter subset selection in PBPK models.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Comparative review of human health reference values of the United States.Toxicological sciences : an official journal of the Society of Toxicology · 2025Review
- Multigenerational exposure to trace concentrations of DDT residues in Wistar rats: Effects on biometric development and biochemical parameters.Toxicology reports · 2025Article
- Reducing uncertainty in dose-response assessments by incorporating Bayesian benchmark dose modeling and in vitro data on population variability.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Incorporating new approach methods (NAMs) data in dose-response assessments: The future is now!Journal of toxicology and environmental health. Part B, Critical reviews · 2025Review
- Advancing quantitative hazard banding using expanded probabilistic reference doses and high-throughput screening data for preliminary hazard assessment.NAM journal · 2025Article
- Two-Stage Machine Learning-Based Approach to Predict Points of Departure for Human Noncancer and Developmental/Reproductive Effects.Environmental science & technology · 2024Article
- Guidance on risk-benefit assessment of foods.EFSA journal. European Food Safety Authority · 2024Article
- Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances.Environmental science & technology · 2024Article
- Adverse effects in traditional and alternative toxicity tests.Regulatory toxicology and pharmacology : RTP · 2024Article
- Invited Perspective: Uneven Progress Addressing Population Variability in Human Health Risk Assessment.Environmental health perspectives · 2024Article
- Advancing probabilistic risk assessment by integrating human biomonitoring, new approach methods, and Bayesian modeling: A case study with the mycotoxin deoxynivalenol.Environment international · 2023Article
- A mode of action-based probabilistic framework of dose-response assessment for nonmutagenic liver carcinogens: a case study of PCB-126.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Bayesian-Based Probabilistic Risk Assessment of Fipronil in Food: A Case Study in Taiwan.Toxics · 2023Article
- Beyond the cancer slope factor: Broad application of Bayesian and probabilistic approaches for cancer dose-response assessment.Environment international · 2023Article
- A value of information framework for assessing the trade-offs associated with uncertainty, duration, and cost of chemical toxicity testing.Risk analysis : an official publication of the Society for Risk Analysis · 2023Article
- Probabilistic Points of Departure and Reference Doses for Characterizing Human Noncancer and Developmental/Reproductive Effects for 10,145 Chemicals.Environmental health perspectives · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe National Academies recommended risk assessments redefine the traditional noncancer Reference Dose (RfD) as a probabilistically derived risk-specific dose, a framework for which was recently developed by the World Health Organization (WHO).
objectivesOur aim was to assess the feasibility and implications of replacing traditional RfDs with probabilistic estimates of the human dose associated with an effect magnitude M and population incidence I (HD
methodsWe created a comprehensive, curated database of RfDs derived from animal data and developed a standardized, automated, web-accessible probabilistic dose-response workflow implementing the WHO framework.
resultsWe identified 1,464 RfDs and associated endpoints, representing 608 chemicals across many types of effects. Applying our standardized workflow resulted in 1,522 HD
conclusionsOverall, replacing RfDs with HD
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.