Evidence map›Paper›PMID 29968402›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2018

Circulating Tumor Cell Phenotyping via High-Throughput Acoustic Separation.

Mengxi Wu, Po-Hsun Huang, Rui Zhang, Zhangming Mao, Chuyi Chen, Gabor Kemeny, Peng Li, Adrian V Lee, Rekha Gyanchandani, Andrew J Armstrong and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
  2. Review
  3. Acoustofluidic Biosensors.Micromachines · 2026
    Review
  4. Article
  5. Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Mengxi WuDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
Po-Hsun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
Rui ZhangDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Zhangming MaoDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.
Chuyi ChenDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.
Gabor KemenyDuke Cancer Institute and Departments of Medicine, Surgery, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA.
Peng LiEugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
Adrian V LeeDepartment of Pharmacology & Chemical Biology, Magee-Women's Research Institute, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Rekha GyanchandaniDepartment of Pharmacology & Chemical Biology, Magee-Women's Research Institute, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Andrew J ArmstrongDuke Cancer Institute and Departments of Medicine, Surgery, and Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA.
Ming DaoDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Subra SureshNanyang Technological University, 50 Nanyang Avenue, Main Campus, Singapore, 639798, Singapore.
Tony Jun HuangDepartment of Mechanical Engineering and Material Science, Duke University, Durham, NC, 27708, USA.ORCID 0000-0003-1205-3313

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI DONNA NIEDZWIECKI · 1985 to 2026
$174.8M
Extracellular vesicles and their ncRNA cargo as markers of trophoblast injuryR01HD086325 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SADOVSKY, YOEL · 2015 to 2019
$3.6M
Standing Surface Acoustic Wave Based Cell Sorters for Maintaining Cell IntegrityR01GM112048 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2017
$1.1M
Validation of acoustic tweezers for single-cell analyses of purine metabolismR33EB019785 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI HUANG, TONY JUN · 2014 to 2016
$1.1M
NCI NIH HHS P30 CA014236NIBIB NIH HHS R33 EB019785NICHD NIH HHS R01 HD086325NIGMS NIH HHS R01 GM112048
6 · The paper itself

Abstract

The study of circulating tumor cells (CTCs) offers pathways to develop new diagnostic and prognostic biomarkers that benefit cancer treatments. In order to fully exploit and interpret the information provided by CTCs, the development of a platform is reported that integrates acoustics and microfluidics to isolate rare CTCs from peripheral blood in high throughput while preserving their structural, biological, and functional integrity. Cancer cells are first isolated from leukocytes with a throughput of 7.5 mL h

Indexed as

AcousticsCell Line, TumorCell SeparationComputer SimulationDimethylpolysiloxanesGlassHigh-Throughput Screening AssaysHumansLeukocytesMaleNeoplastic Cells, CirculatingNumerical Analysis, Computer-AssistedPhenotypeProstatic NeoplasmsRheologyDimethylpolysiloxanesacoustofluidicscancer phenotypingcirculating tumor cellshigh-throughput separationmicrofluidics

Identifiers

PMID29968402
PMCPMC6105522

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.