Evidence map›Paper›PMID 29968377›Full record

ArticleBritish journal of pharmacology2018

Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells.

Jia-Wei Zeng, Bao-Yi Chen, Xiao-Fei Lv, Lu Sun, Xue-Lin Zeng, Hua-Qing Zheng, Yan-Hua Du, Guan-Lei Wang, Ming-Ming Ma, Yong-Yuan Guan

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The role of anoctamin 1 in liver disease.Journal of cellular and molecular medicine · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Research progress in apoptosis of vascular smooth muscle cells in atherosclerosis.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  10. The CaActa pharmaceutica Sinica. B · 2021
    Review
  11. Article
  12. Review
  13. CaJournal of advanced research · 2021
    Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jia-Wei ZengDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Bao-Yi ChenDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xiao-Fei LvDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Lu SunDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xue-Lin ZengDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Hua-Qing ZhengDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yan-Hua DuDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Guan-Lei WangDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Ming-Ming MaDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-0237-0940
Yong-Yuan GuanDepartment of Pharmacology, Cardiac & Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0002-0079-1653
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeTransmembrane member 16A (TMEM16A), an intrinsic constituent of the Ca EXPERIMENTAL APPROACH: Cell viability assay, flow cytometry, Western blot, mitochondrial membrane potential assay, immunogold labelling and co-immunoprecipitation (co-IP) were performed. KEY

resultsHydrogen peroxide (H CONCLUSIONS AND IMPLICATIONS: These results suggest that TMEM16A participates in H

Indexed as

AnimalsAnoctamin-1ApoptosisCells, CulturedCyclophilinsCytochromes cHydrogen PeroxideMaleMembrane Potential, MitochondrialMiceMice, Inbred C57BLMice, TransgenicMitochondria, MuscleMuscle, Smooth, VascularPeptidyl-Prolyl Isomerase FRatsANO1 protein, mouseAnoctamin-1CyclophilinsCytochromes cHydrogen PeroxidePeptidyl-Prolyl Isomerase FPPIF protein, mouse

Identifiers

PMID29968377
PMCPMC6109215
OpenAlexW2809719075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.