ReviewThe Journal of physiology2019
The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points.
Review in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Urinary Titin N-Fragment Evaluation in a Randomized Controlled Trial of Beta-Hydroxy-Beta-Methylbutyrate for Acute Mild Trauma in Older Adults.Nutrients · 2021Trial
- Triglyceride-related metabolic indices and low relative muscle mass: a cross-sectional analysis of SMILE and NHANES.Endocrine · 2026Article
- Article
- Light intensity and cage position affect meat quality by regulating intestinal flora, inflammation and oxidation in broilers.Frontiers in microbiology · 2026Article
- Cross-Education of Strength: From Theory to Practice in Contemporary Sports Rehabilitation-A Narrative Review and Clinical Implications.Sports medicine - open · 2025Review
- MuRF1 Partners With TRIM72 to Impair Insulin Signaling in Skeletal Muscle Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Daily blood flow restriction does not preserve muscle mass and strength during 2 weeks of bed rest.The Journal of physiology · 2025Article
- Characterizing 24-Hour Skeletal Muscle Gene Expression Alongside Metabolic and Endocrine Responses Under Diurnal Conditions.The Journal of clinical endocrinology and metabolism · 2025Article
- Individualized supplement of water-soluble vitamins: the influence of inflammation and renal function on circulating concentrations in critically digestive disease patients.Frontiers in immunology · 2025Article
- Postoperative day of surgery ambulation improves outcomes following lung resection: a multicenter prospective cohort study.Journal of thoracic disease · 2024Article
- DYNamic Assessment of Multi-Organ level dysfunction in patients recovering from COVID-19: DYNAMO COVID-19.Experimental physiology · 2024Article
- Five days of bed rest in young and old adults: Retainment of skeletal muscle mass with neuromuscular electrical stimulation.Physiological reports · 2024Article
- Alternative Treatments to Exercise for the Attenuation of Disuse-Induced Skeletal Muscle Atrophy in Rats.Muscles (Basel, Switzerland) · 2024Article
- Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.American journal of physiology. Endocrinology and metabolism · 2024Article
- Inflammation and altered metabolism impede efficacy of functional electrical stimulation in critically ill patients.Critical care (London, England) · 2023Article
- Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice.NPJ microgravity · 2023Article
- Effects of Probiotic Supplementation on Exercise and the Underlying Mechanisms.Foods (Basel, Switzerland) · 2023Review
- Multisystem physiological perspective of human frailty and its modulation by physical activity.Physiological reviews · 2023Review
- Association between the dietary inflammatory index and disability in Japanese older people.Public health nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of muscle mass and insulin sensitivity are common phenotypic traits of immobilisation and increased inflammatory burden. The suppression of muscle protein synthesis is the primary driver of muscle mass loss in human immobilisation, and includes blunting of post-prandial increases in muscle protein synthesis. However, the mechanistic drivers of this suppression are unresolved. Immobilisation also induces limb insulin resistance in humans, which appears to be attributable to the reduction in muscle contraction per se. Again mechanistic insight is missing such that we do not know how muscle senses its "inactivity status" or whether the proposed drivers of muscle insulin resistance are simply arising as a consequence of immobilisation. A heightened inflammatory state is associated with major and rapid changes in muscle protein turnover and mass, and dampened insulin-stimulated glucose disposal and oxidation in both rodents and humans. A limited amount of research has attempted to elucidate molecular regulators of muscle mass loss and insulin resistance during increased inflammatory burden, but rarely concurrently. Nevertheless, there is evidence that Akt (protein kinase B) signalling and FOXO transcription factors form part of a common signalling pathway in this scenario, such that molecular cross-talk between atrophy and insulin signalling during heightened inflammation is believed to be possible. To conclude, whilst muscle mass loss and insulin resistance are common end-points of immobilisation and increased inflammatory burden, a lack of understanding of the mechanisms responsible for these traits exists such that a substantial gap in understanding of the pathophysiology in humans endures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.