Evidence map›Paper›PMID 29968226›Full record

ReviewEndocrine2018

Sentinel lymph node biopsy in small papillary thyroid cancer. A review on novel surgical techniques.

Ludovico Maria Garau, Domenico Rubello, Alice Ferretti, Giuseppe Boni, Duccio Volterrani, Gianpiero Manca

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Endocrine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07391514 (Deep Learning-Based Intraoperative Dual-tracer Video Analysis of Sentinel Lymph Node Mapping for Metastasis Prediction in cN0 Papillary Thyroid Carcinoma), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07391514 completednot on this mapstarted 2024, after this paper: background citation

Deep Learning-Based Intraoperative Dual-tracer Video Analysis of Sentinel Lymph Node Mapping for Metastasis Prediction in cN0 Papillary Thyroid Carcinoma: A Prospective Cohort Study

Typeobservational_patient_registrySponsorFirst Affiliated Hospital of Chongqing Medical UniversityRan2024 to 2024Enrolled131ConditionsPapillary Thyroid CarcinomaArmsIndocyanine green (ICG) sentinel lymph node mapping, Carbon nanoparticle (CNs) sentinel lymph node mapping, Dual-tracer (ICG combined with CNs) sentinel lymph node mapping
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. [Clinical feasibility of imaging with indocyanine green combined with methylene blue for sentinel lymph node identification in papillary thyroid microcarcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
    Trial
  3. Trial
  4. Article
  5. Virtual histology imaging of lymph nodesCancer biology & medicine · 2026
    Observational
  6. Article
  7. Article
  8. Sentinel lymph node detection in thyroid carcinoma using [European journal of nuclear medicine and molecular imaging · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Sentinel Lymph Node Biopsy in Thyroid Cancer.World journal of surgery · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ludovico Maria GarauRegional Center of Nuclear Medicine, Hospital University of Pisa, Pisa, Italy. ludovico.garau@gmail.com.
Domenico RubelloDepartment of Nuclear Medicine and PET Center, Radiology, Medical Physics, Clinical Pathology, S. Maria della Misericordia Hospital, Rovigo, Italy. domenico.rubello@libero.it.
Alice FerrettiDepartment of Nuclear Medicine and PET Center, Radiology, Medical Physics, Clinical Pathology, S. Maria della Misericordia Hospital, Rovigo, Italy.
Giuseppe BoniRegional Center of Nuclear Medicine, Hospital University of Pisa, Pisa, Italy.
Duccio VolterraniRegional Center of Nuclear Medicine, Hospital University of Pisa, Pisa, Italy.
Gianpiero MancaRegional Center of Nuclear Medicine, Hospital University of Pisa, Pisa, Italy.
Azienda Ospedaliera Universitaria Pisana · ITOspedale Santa Maria della Misericordia di Rovigo · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSentinel lymph node biopsy (SNB) in patients with papillary thyroid carcinoma (PTC) and negative for clinically neck lymph node metastatic involvement (N0) has emerged as a promising minimally invasive procedure to detect metastatic nodes.

methodsThe MEDLINE database was searched via the PubMed interface on 10 January 2018 for the MeSH headings "sentinel lymph node biopsy" and "thyroid carcinoma".

resultsVital blue dye, radioisotope, and the combination of both techniques are used in PTC patients. These methods and the emerging role of SPECT/CT are discussed in this review. The sentinel lymph node (SLN) identification rates ranged from 0 to 100% for blue dye, 83 to 100% for radioisotopes, and 66 to 100% for the combination of both techniques, respectively.

conclusionsSNB based on radioisotope technique with the use of intraoperative gamma-probe is an accurate and safe method that allows the highest SLN detection rate. There is sufficient evidence to propagate the increasing use of SNB procedure that has the potential to avoid prophylactic lymph node surgery in patients clinically N0.

Indexed as

Sentinel Lymph Node BiopsyHumansIncidenceLymphatic MetastasisLymph NodesPredictive Value of TestsThyroid Cancer, PapillaryTumor BurdenGamma-probe techniqueLymphoscintigraphySentinel lymph node biopsyThyroid carcinomaVital blue dye technique

Identifiers

PMID29968226
OpenAlexW2810234938

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.