Evidence map›Paper›PMID 29968223›Full record

SynthesisHeart failure reviews2018

Prognostic value of T1 mapping and extracellular volume fraction in cardiovascular disease: a systematic review and meta-analysis.

Baiyan Zhuang, Arlene Sirajuddin, Shuli Wang, Andrew Arai, Shihua Zhao, Minjie Lu

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Utility of Cardiac CT for Cardiomyopathy Phenotyping.Tomography (Ann Arbor, Mich.) · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Bioimpedance Spectroscopy Reveals Important Association of Fluid Status and TJournal of magnetic resonance imaging : JMRI · 2022
    Observational
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. CMR TEuropean radiology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baiyan ZhuangDepartment of Magnetic Resonance Imaging, Fuwai Hospital,Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167, Beilishi Road, Beijing, 100037, China.
Arlene SirajuddinDepartment of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart,Lung, and Blood Institute (NHLBI), National Institutes of Health(NIH), 10 Center Drive, Bethesda, 20892, Maryland, United States.
Shuli WangDepartment of Magnetic Resonance Imaging, Fuwai Hospital,Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167, Beilishi Road, Beijing, 100037, China.
Andrew AraiDepartment of Health and Human Services, Laboratory for Advanced Cardiovascular Imaging, National Heart,Lung, and Blood Institute (NHLBI), National Institutes of Health(NIH), 10 Center Drive, Bethesda, 20892, Maryland, United States. araia@nhlbi.nih.gov.
Shihua ZhaoDepartment of Magnetic Resonance Imaging, Fuwai Hospital,Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167, Beilishi Road, Beijing, 100037, China. cjr.zhaoshihua@vip.163.com.
Minjie LuDepartment of Magnetic Resonance Imaging, Fuwai Hospital,Cardiovascular Imaging and Intervention Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167, Beilishi Road, Beijing, 100037, China. coolkan@163.com.

Funding

Technical Development of Diagnostic Cardiovascular MRIZIAHL004607 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2009 to 2020
$25.3M
Advanced Cardiovascular Imaging FellowshipZIEHL006139 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2011 to 2020
$8.8M
6 · The paper itself

Abstract

T1 mapping and extracellular volume (ECV) fraction are useful new magnetic resonance imaging (MRI) techniques to evaluate myocardial fibrosis; however, their prognostic value has not been well described. In this study, a systematic review and meta-analysis evaluating the prognostic value of these techniques is performed in patients with ischemic and non-ischemic cardiomyopathy. PubMed, Cochrane CENTRAL, and Meta-Register of Controlled Trials were searched for studies that utilized T1 mapping and ECV and that also had ≥ 12 months of follow-up data. The primary endpoints included were cardiovascular death and non-fatal cardiac events (heart failure, acute coronary syndrome). Six studies involving a total of 1524 patients and a mean follow-up of 26.3 months were included. Patients had a mean age of 57.6 years and 56.5% were male. Summary effect estimates were generated with fixed/random-effects modeling and hazard ratios were assessed. Patients with a higher ECV value had a significantly higher incidence of cardiovascular death (hazard ratio [HR] 1.79 [95% CI 1.24 to 2.58; P = 0.09) and combined cardiac events (HR 1.11 [95% CI 1.08-1.15]; P < 0.0001). Patients with higher native T1 values and (HR 1.06 [95% CI 0.96 to 1.17]; P = 0.27) and lower post contrast T1 value (HR 0.99 [95% CI 0.98-0.99], P < 0.001) overall had no increased risk for cardiovascular events. Comparing with other CMR parameters, ECV has excellent potential prognostic value and can help guide risk stratification of patients with ischemic or non-ischemic cardiomyopathy into high and low risk for adverse cardiovascular events.

Indexed as

CardiomyopathiesExtracellular MatrixHumansMagnetic Resonance Imaging, CineMyocardiumPrognosisCardiac magnetic resonance (CMR) imagingHypertrophic cardiomyopathyIdiopathic dilated cardiomyopathyInfiltrative cardiomyopathyMeta-analysis

Identifiers

PMID29968223

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.