Evidence map›Paper›PMID 29968018›Full record

ReviewJournal of bioethical inquiry2018

Ethical Issues of Using CRISPR Technologies for Research on Military Enhancement.

Marsha Greene, Zubin Master

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bioethical inquiry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. CRISPR: Beyond the Excitement.Journal of bioethical inquiry · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Ethics of Gene Therapy in the Military: Promise and Potential Problems.Molecular therapy : the journal of the American Society of Gene Therapy · 2020
    Article
  9. Bioethical issues in genome editing by CRISPR-Cas9 technology.Turkish journal of biology = Turk biyoloji dergisi · 2020
    Article
  10. CRISPR in the North American popular press.Genetics in medicine : official journal of the American College of Medical Genetics · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marsha GreeneSenior Policy Analyst, Peraton, Contracted to the Office of the Under Secretary of Defense for Research and Engineering, 4800 Mark Center Drive, Suite 17E08, Alexandria, VA, 22350-3600, USA.
Zubin MasterBiomedical Ethics Research Program, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. master.zubin@mayo.edu.ORCID http://orcid.org/0000-0002-3462-4546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents an overview of the key ethical questions of performing gene editing research on military service members. The recent technological advance in gene editing capabilities provided by CRISPR/Cas9 and their path towards first-in-human trials has reinvigorated the debate on human enhancement for non-medical purposes. Human performance optimization has long been a priority of military research in order to close the gap between the advancement of warfare and the limitations of human actors. In spite of this focus on temporary performance improvement, biomedical enhancement is an extension of these endeavours and the ethical issues of such research should be considered. In this paper, we explore possible applications of CRISPR to military human gene editing research and how it could be specifically applied towards protection of service members against biological or chemical weapons. We analyse three normative areas including risk-benefit analysis, informed consent, and inequality of access as it relates to CRISPR applications for military research to help inform and provide considerations for military institutional review boards and policymakers.

Indexed as

Bioethical IssuesClustered Regularly Interspaced Short Palindromic RepeatsMilitary PersonnelBiomedical EnhancementBiomedical ResearchEthics, ResearchGene EditingHumansMilitary MedicineWarfareCRISPR/Cas 9EnhancementEthics of research involving humansInformed consentMilitaryRisk–benefit analysis

Identifiers

PMID29968018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.