Evidence map›Paper›PMID 29967991›Full record

ArticleSurgical endoscopy2019

Short-term outcomes of transanal completion total mesorectal excision (cTaTME) for rectal cancer: a case-matched analysis.

T W A Koedam, M Veltcamp Helbach, M Penna, A Wijsmuller, P Doornebosch, H L van Westreenen, R Hompes, H J Bonjer, C Sietses, E de Graaf and 1 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Completion Total Mesorectal Excision: A Case-Matched Comparison With Primary Resection.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2023
    Article
  9. Mesentery in Transanal TME.Clinics in colon and rectal surgery · 2022
    Review
  10. Review
  11. Article
  12. Outcomes of completion total mesorectal excision are not compromised by prior transanal minimally invasive surgery.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2020
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

T W A KoedamDepartment of Surgery, VU University Medical Center, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. t.koedam@vumc.nl.
M Veltcamp HelbachDepartment of Surgery, Hospital Gelderse Vallei, Ede, The Netherlands.
M PennaDepartment of Colorectal Surgery, Churchill Hospital, Oxford, UK.
A WijsmullerDepartment of Surgery, VU University Medical Center, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
P DoorneboschDepartment of Surgery, IJsselland Hospital, Capelle a/d IJssel, The Netherlands.
H L van WestreenenDepartment of Surgery, ISALA Hospital, Zwolle, The Netherlands.
R HompesDepartment of Colorectal Surgery, Churchill Hospital, Oxford, UK.
H J BonjerDepartment of Surgery, VU University Medical Center, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
C SietsesDepartment of Surgery, Hospital Gelderse Vallei, Ede, The Netherlands.
E de GraafDepartment of Surgery, IJsselland Hospital, Capelle a/d IJssel, The Netherlands.
J B TuynmanDepartment of Surgery, VU University Medical Center, Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLChurchill Hospital · GBIJsselland Ziekenhuis · NLZiekenhuis Gelderse Vallei · NLIsala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLocal excision of early rectal tumors as a rectal preserving treatment is gaining popularity, especially since bowel cancer screening programs result in a shift towards the diagnosis of early stage rectal cancers. However, unfavorable histological features predicting high risk for recurrence within the "big biopsy" may mandate completion total mesorectal excision (cTME). Completion surgery is associated with higher morbidity, poorer specimen quality, and less favorable oncological outcomes compared to primary TME. Transanal approach potentially improves outcome of completion surgery for rectal cancer. The aim of this study was to compare radical completion surgery after local excision for rectal cancer by the transanal approach (cTaTME) with conventional abdominal approach (cTME).

methodsAll consecutive patients who underwent cTaTME for rectal cancer between 2012 and 2017 were case-matched with cTME patients, according to gender, tumor height, preoperative radiotherapy, and tumor stage. Surgical, pathological, and short-term postoperative outcomes were evaluated.

resultsIn total, 25 patients underwent completion TaTME and were matched with 25 patients after cTME. Median time from local excision to completion surgery was 9 weeks in both groups. In the cTaTME and cTME groups, perforation of the rectum occurred in 4 and 28% of patients, respectively (p = 0.049), leading to poor specimen quality in these patients. Number of harvested lymph nodes was higher after cTaTME (median 15; range 7-47) than after cTME (median 10; range 0-17). No significant difference was found in end colostomy rate between the two groups. Major 30-day morbidity (Clavien-Dindo≥ III) was 20 and 32%, respectively (p = 0.321). Hospital stay was significantly longer after cTME.

conclusionTaTME after full-thickness excision is a promising technique with a significantly lower risk of perforation of the rectum and better specimen quality compared to conventional completion TME.

Indexed as

AgedAged, 80 and overCase-Control StudiesDigestive System Surgical ProceduresFemaleHumansLength of StayMaleMiddle AgedNeoplasm Recurrence, LocalPostoperative ComplicationsProspective StudiesRectal NeoplasmsRectumTransanal Endoscopic SurgeryCompletionOutcomesRectal surgeryTAMISTaTME

Identifiers

PMID29967991
PMCPMC6336745
OpenAlexW2811131409

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.