Evidence map›Paper›PMID 29967975›Full record

ArticleClinical oral investigations2019

Antimicrobial susceptibilities of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis strains from periodontitis patients in Morocco.

M Mínguez, O K Ennibi, P Perdiguero, L Lakhdar, L Abdellaoui, M C Sánchez, M Sanz, David Herrera

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In one paragraph

Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. The Antimicrobial Susceptibility ofAntibiotics (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Journal of Indian Society of Periodontology
    Article
  11. Prevalence of metronidazole resistance genes inJournal of Indian Society of Periodontology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

M MínguezSection of Periodontology, Faculty of Odontology, University Complutense, Ciudad Universitaria, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.
O K EnnibiEREB (Oral Ecosystem) Research Group, Faculty of Medicine Dentistry, Mohammed V University, Rabat, Morocco.
P PerdigueroLaboratory of Research, Faculty of Odontology, University Complutense, Madrid, Spain.
L LakhdarEREB (Oral Ecosystem) Research Group, Faculty of Medicine Dentistry, Mohammed V University, Rabat, Morocco.
L AbdellaouiEREB (Oral Ecosystem) Research Group, Faculty of Medicine Dentistry, Mohammed V University, Rabat, Morocco.
M C SánchezLaboratory of Research, Faculty of Odontology, University Complutense, Madrid, Spain.
M SanzSection of Periodontology, Faculty of Odontology, University Complutense, Ciudad Universitaria, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.
David HerreraSection of Periodontology, Faculty of Odontology, University Complutense, Ciudad Universitaria, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain. davidher@ucm.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveAggregatibacter actinomycetemcomitans and Porphyromonas gingivalis have been frequently isolated in periodontitis patients in Morocco. Its persistence after the subgingival debridement of the biofilm has been correlated with worse clinical outcomes. The aim of this study was to evaluate the antimicrobial susceptibilities of A. actinomycetemcomitans and P. gingivalis, to amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin. In addition, microbiological profiles of patients harbouring A. actinomycetemcomitans, P. gingivalis, or both were compared. MATERIAL AND

methodsIn 45 consecutive periodontitis Moroccan patients, subgingival samples were taken and processed by culture. Twenty-four A. actinomycetemcomitans and 30 P. gingivalis colonies were isolated (54 strains) and susceptibility tests, using the epsilometric method, were run for amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin. Minimum inhibitory concentrations for 50 (MIC50) and 90% (MIC90) of the organisms were calculated.

resultsThe prevalence of A. actinomycetemcomitans and P. gingivalis was 79.5 and 84.4%, respectively. A. actinomycetemcomitans showed susceptibility to amoxicillin, amoxicillin plus clavulanate, while 28% of the isolated strains were resistant to azithromycin and 61.7% towards metronidazole. No P. gingivalis resistance towards amoxicillin, amoxicillin plus clavulanate, metronidazole, and azithromycin was found.

conclusionA. actinomycetemcomitans and P. gingivalis were frequently detected in Moroccan patients with periodontitis, while antimicrobial resistance was only detected for A. actinomycetemcomitans to metronidazole and azithromycin. CLINICAL RELEVANCE: A. actinomycetemcomitans resistance against some antimicrobials in periodontitis patients in Morocco can influence the selection of the therapeutic approaches.

Indexed as

PeriodontitisPorphyromonas gingivalisAggregatibacter actinomycetemcomitansAnti-Infective AgentsHumansMoroccoAnti-Infective AgentsAggregatibacter actinomycetemcomitansAntimicrobial susceptibilitiesMoroccoPeriodontitisPorphyromonas gingivalis

Identifiers

PMID29967975

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.