Evidence map›Paper›PMID 29967971›Full record

ArticleMycopathologia2019

Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents.

Beth K Thielen, Aaron M T Barnes, Arick P Sabin, Becky Huebner, Susan Nelson, Elizabeth Wesenberg, Glen T Hansen

Open access · greenAbstract readCase Reports
In one paragraph

Article in Mycopathologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Isavuconazole-Animal Data and Clinical Data.Journal of fungi (Basel, Switzerland) · 2020
    Review
  6. Review
  7. Review
  8. Mucormycosis in Burn Patients.Journal of fungi (Basel, Switzerland) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Beth K ThielenDepartment of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA. thie0149@umn.edu.ORCID http://orcid.org/0000-0001-5922-0241
Aaron M T BarnesDepartment of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0002-7014-7556
Arick P SabinDepartment of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.
Becky HuebnerDepartment of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.
Susan NelsonDepartment of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.
Elizabeth WesenbergDepartment of Pathology & Laboratory Medicine, Hennepin County Medical Center, Minneapolis, MN, 55415, USA.
Glen T HansenDepartment of Medicine (Division of Infectious Diseases and International Medicine), University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.
University of Minnesota · USHennepin County Medical Center · US

Funding

Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
NIAID NIH HHS T32 AI055433
6 · The paper itself

Abstract

The Mucorales fungi-formerly classified as the zygomycetes-are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often despite surgical and antifungal therapy. Patients with extensive burn injuries are particularly susceptible to skin and soft-tissue infections with these organisms. Here, we present a case of Lichtheimia infection in a patient with extensive full-thickness burns that required significant and repeated surgical debridement successfully treated with isavuconazole and adjunctive topical amphotericin B washes. We also review the available literature on contemporary antifungal treatment for Lichtheimia species and related Mucorales fungi.

Indexed as

Amphotericin BAntifungal AgentsBurnsDebridementDermatomycosesHumansMaleMiddle AgedMucoralesMucormycosisNitrilesPyridinesTreatment OutcomeTriazolesAmphotericin BAntifungal AgentsisavuconazoleNitrilesPyridinesTriazolesAbsidiaBurnIsavuconazoleLichtheimiaMucorales

Identifiers

PMID29967971
PMCPMC6445638
OpenAlexW2810883741

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.