ArticleJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2016
Congenital Heart Disease Requiring Maintenance of Ductus Arteriosus in Critically Ill Newborns Admitted at a Tertiary Neonatal Intensive Care Unit.
Article in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Outcomes of Primary Vs. Staged Repair in 4628 Neonates with Symptomatic Tetralogy of Fallot: A Systematic Review and Meta-analysis.Pediatric cardiology · 2026Pooled it
- Pre-procedural three-dimensional computed tomography vs. angiographic assessment for patent ductus arteriosus stenting: a comparative analysis.Frontiers in cardiovascular medicine · 2026Article
- Point-of-Care Ultrasound Optimizes the Preoperative Use of Prostaglandin E1 in Infants With Transposition of the Great Arteries.Reviews in cardiovascular medicine · 2025Article
- Tetralogy of Fallot: The Burden of Pulmonary Atresia in the NICU Set-Up: Two Case Reports and a Literature Review.Children (Basel, Switzerland) · 2025Review
- Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Repair of aortic coarctation in neonates less than two kilograms.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Effectiveness of Alprostadil for Ductal Patency.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Cumulative Dose of Prostaglandin E1 Determines Gastrointestinal Adverse Effects in Term and Near-Term Neonates Awaiting Cardiac Surgery: A Retrospective Cohort Study.Children (Basel, Switzerland) · 2023Article
- Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site IJournal of the American Heart Association · 2023Article
- Management of tetralogy of Fallot in the pediatric intensive care unit.Frontiers in pediatrics · 2023Review
- Management of ductal spasm in a neonate with pulmonary atresia and an intact ventricular septum during cardiac catheterization: A case report.World journal of clinical cases · 2022Article
- Increasing Alprostadil Requirements in a Neonate With Cardiac Anomalies and Co-administration of Rectal and Oral Acetaminophen.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Diagnosis and Management of Critical Congenital Heart Diseases in the Newborn.Indian journal of pediatrics · 2020Review
- Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2.Frontiers in pediatrics · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCongenital heart diseases (CHD) have been reported to be responsible for 30 to 50% of infant mortality caused by congenital disabilities. In critical cases, survival of newborns with CHD depends on the patency of the ductus arteriosus (PDA), for maintaining the systemic or pulmonary circulation. The aim of the study was to assess the efficacy and side effects of PGE (prostaglandin E) administration in newborns with critical congenital heart disease requiring maintenance of the ductus arteriosus. MATERIAL AND
methodAll clinical and paraclinical data of 66 infants admitted to one referral tertiary level academic center and treated with Alprostadil were analyzed. Patients were divided into three groups: Group 1: PDA dependent pulmonary circulation (n=11) Group 2: PDA dependent systemic circulation (n=31) Group 3: PDA depending mixed circulation (n=24).
resultsThe mean age of starting PGE1 treatment was 2.06 days, 1.91 (+/-1.44) days for PDA depending pulmonary flow, 2.39 (+/-1.62) days for PDA depending systemic flow and 1.71 (+/1.12) for PDA depending mixing circulation. PEG1 initiation was commenced 48 hours after admission for 72%, between 48-72 hours for 6%, and after 72 to 120 hours for 21% of newborns detected with PDA dependent circulation. Before PEG1 initiation the mean initial SpO2 was 77.89 (+/- 9.2)% and mean initial oxygen pressure (PaO2) was 26.96(+/-6.45) mmHg. At the point when stable wide open PDA was achieved their mean SpO2increased to 89.73 (+/-8.4)%, and PaO2 rose to 49 (+/-7.2) mmHg. During PGE1 treatment, eleven infants (16.7%) had apnea attacks, five children (7.5%) had convulsions, 33 (50%) had fever, 47 (71.2%) had leukocytosis, 52 (78.8%) had edema, 25.8% had gastrointestinal intolerance, 45.5% had hypokalemia, and 63.6% had irritability.
conclusionsFor those infants with severe cyanosis or shock caused by PDA dependent heart lesions, the initiation and maintenance of PGE1 infusion is imperative. The side effects of this beneficial therapy were transient and treatable.
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