ArticleJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2016
Can APACHE II, SOFA, ISS, and RTS Severity Scores be used to Predict Septic Complications in Multiple Trauma Patients?
Article in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Association of thiamine supplementation with 30-day mortality among ICU patients with sepsis-associated delirium.Scientific reports · 2026Article
- Thrombocytopenia in Sepsis.Life (Basel, Switzerland) · 2025Review
- Prediction of posttraumatic functional recovery in middle-aged and older patients through dynamic ensemble selection modeling.Frontiers in public health · 2023Article
- Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma.Frontiers in immunology · 2023Article
- Comparison the Ability of Quantitative Trauma Severity Assessment Methods Based On GAP, RTS, and ISS Criteria in Determining the Prognosis of Accidental Patients.Bulletin of emergency and trauma · 2022Article
- Predictive performance of SOFA and qSOFA for in-hospital mortality in severe novel coronavirus disease.The American journal of emergency medicine · 2020Article
- Hemodynamic Predictors for Sepsis-Induced Acute Kidney Injury: A Preliminary Study.Journal of clinical medicine · 2020Article
- Denver and Marshall scores successfully predict susceptibility to multiple independent infections in trauma patients.PloS one · 2020Article
- Have Severity Scores a Place in Predicting Septic Complications in ICU Multiple Trauma Patients?Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysiological composite scores are used to predict mortality in multiple trauma patients. Sepsis is the leading cause of late mortality in trauma victims brought about by immune suppression due to homeostasis dysregulation.
objectiveTo determine whether APACHE II, SOFA, ISS and RTS scores can predict the occurrence of sepsis in multiple trauma patients.
methodsAPACHE II, SOFA, ISS, and RTS scores were calculated during the first twenty-four hours after the injury for sixty-four adult poly-traumatic patients. The occurrence of infectious complications was investigated over a fourteen-day period. The infection-free rates for the multiple trauma patients were considered as end-points in the Kaplan-Meier plot analysis.
resultsFor SOFA, a cutoff score of 4 points was identified as a predictor of the occurrence of sepsis, with 89% of the patients with SOFA<4 being infection-free, while 37% of those with SOFA>4 were infection-free (p<0.01). None of the patients with APACHE II≤5 points developed infections. Eighty-four percent of patients with APACHE II scores of 5-10 did not develop sepsis, while 49% with APACHE II≥11 were infection-free (p<0.01). A cutoff of 7 points was found to be most discriminative for RTS. Eighty-eight percent of the patients with RTS≤7 and 43% of those with RTS<7 were infection-free (p<0.01). Eighty-eight percent of patients with ISS≥22 did not develop sepsis and 56% with ISS>22 did not develop sepsis (p<0.01).
conclusionAPACHE II, SOFA, ISS, and RTS functional severity scores can predict mortality as well as the occurrence of sepsis in multiple trauma patients.
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