ArticleJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2015
An Evaluation of Serum Procalcitonin and C-Reactive Protein Levels as Diagnostic and Prognostic Biomarkers of Severe Sepsis.
Article in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The utility of procalcitonin for diagnosing bacteremia and bacterial pneumonia in hospitalized oncology patients.Journal of cancer research and clinical oncology · 2023Article
- Investigating Morphological Changes of T-lymphocytes after Exposure with Bacterial Determinants for Early Detection of Septic Conditions.Microorganisms · 2022Article
- Correlation of serum miR-127 level with severity and prognosis of sepsis.American journal of translational research · 2022Article
- Eliminating viscosity bias in lateral flow tests.Microsystems & nanoengineering · 2021Article
- Observational
- Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis.Immune network · 2020Review
- Towards Lateral Flow Quantitative Assays: Detection Approaches.Biosensors · 2019Review
- A Comparative Review of Equine SIRS, Sepsis, and Neutrophils.Frontiers in veterinary science · 2019Review
- Adenosine Attenuates LPS-Induced Cardiac Dysfunction by Inhibition of Mitochondrial Function via the ER Pathway.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- The Relevance of Coding Gene Polymorphysms of Cytokines and Cellular Receptors in Sepsis.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2017Review
- Sepsis-Associated Coagulopathy.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
- A Fatal Case of Community AcquiredJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
- Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecommendations have been made, following the multicenter Surviving Sepsis Campaign study, to standardize the definition of severe sepsis with reference to several parameters such as haemodynamic stability, acid-base balance, bilirubin, creatinine, International Normalized Ratio (INR), urine output and pulmonary functional value of the ratio between arterial oxigen partial pressure and inspiratory oxigen concentration. Procalcitonin (PCT) is considered to be a gold standard biomarker for the inflammatory response, and recent studies have shown that it may help to discover whether a seriously ill person is developing sepsis. C-reactive protein (CRP) is also used as a marker of inflammation in the body, as its blood levels increase if there is any inflammation in the body. The aim of this study was to evaluate serum procalcitonin and C-reactive protein levels as diagnostic and prognostic biomarkers of severe sepsis. MATERIAL AND
methodSixty patients, diagnosed as being "septic", were admitted to the intensive care unit (ICU). Based on laboratory results and clinical findings a diagnosis of "severe sepsis" was made, and correlated with PCT and CRP values. The APACHE II, SAPS II and SOFA severity scores were calculated, analyzed and correlated with PCT and CRP.
resultsFifty two patients (86.67%) presented with criteria for severe sepsis. Multivariate correlation analysis indicated a significant positive association between procalcitonin and all severity scores (APACHEII p<0.0001, SOFA p<0.0001, SAPS II p<0.0001). CRP proved to be significantly correlated only with the SAPS II score (p=0.0145). Mortality rate was high, with 48 patients (80%) dying. There was no significant correlation between the levels of the PCT and CRP biomarkers and severe sepsis (p=0.2059 for PCT, p=0.6059 for CRP).
conclusionsThe procalcitonin levels are highly correlated with the severity scores (APACHE II, SAPS II, SOFA) regularly used in ICUs and therefore can be used for determining the severity of the septic process. Quantitive procalcitonin and C-reactive protein analysis was not shown to be useful in diagnosing severe sepsis. However, PCT and CRP can be used to predict the fatal progression of the septic patient.
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