ArticleBioMed research international2018
The Pathology of Type II Modic Changes: Fat Deposition or Osteosclerosis? A Study Using CT Scan.
Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Retrospective comparative study of lumbar spine MRI texture analysis in diagnosing bone marrow edema lesions in ankylosing spondylitis and non-ankylosing spondylitis.BMC musculoskeletal disorders · 2025Article
- Correlation Between Bone Mineral Density And Different Types of Modic Changes in Lumbar Spine.Current medical imaging · 2025Article
- Proteomic analysis of serum in a population-based cohort did not reveal a biomarker for Modic changes.JOR spine · 2024Article
- Type 2 sclerotic Modic change affect fusion result in patients undergoing PLIF with pedicle screw instrumentation: a retrospective study.BMC musculoskeletal disorders · 2021Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designA retrospective cross-sectional study of type II Modic changes (MCs).
objectiveTo evaluate the CT values of type II MCs and determine their relationship with disc degeneration.
methods124 type II MCs from 66 patients' MRI and CT were included and analyzed. Disc degeneration adjacent to MCs was evaluated based on Pfirrmann classification. CT values of bone marrow area and endplate from MC regions, adjacent non-MC regions, and L1 vertebra were measured. CT value changes (ΔCT value) were defined as MCs' CT value minus non-MCs'. According to the types of variables, paired t-test, signed-rank test, two-way ANOVA, and Friedman test were used.
resultsThe CT value of MCs was significantly higher than that of non-MCs at both bone marrow area and endplate (P<0.0001, resp.). Good consistency was found between non-MCs and L1 vertebra in the CT value of bone marrow area and endplate (P=0.2129, P=0.2272, resp.), suggesting the control group was valid. Adjacent to type II MCs, there were 8 (6.4%) discs with grade III degeneration, 58 (46.8%) with grade IV, and 58 (46.8%) with grade V. The ΔCT value of grade V disc degeneration was larger than that of grade IV at the endplate (P=0.0150).
conclusionsOsteosclerosis may exist in type II MCs. The more severe the degeneration of the adjacent disc, the greater the degree of osteosclerosis.
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