Evidence map›Paper›PMID 29967636›Full record

ArticleGastroenterology research and practice2018

Overweight or Obese Individuals at Eighteen Years of Age Develop Pancreatic Adenocarcinoma at a Significantly Earlier Age.

David T Chao, Nilesh H Shah, Herbert J Zeh, Aatur D Singhi, Nathan Bahary, Kevin M McGrath, Kenneth E Fasanella, Amer H Zureikat, David C Whitcomb, Randall E Brand

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastroenterology research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The Relationship between Sleep, Obesity, and Metabolic Health in Adolescents - a Review.Current opinion in endocrine and metabolic research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

David T ChaoDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nilesh H ShahDepartment of Dental Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Herbert J ZehDivision of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nathan BaharyDivision of Hematology/Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kevin M McGrathDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Kenneth E FasanellaDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Amer H ZureikatDivision of Gastrointestinal Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
David C WhitcombDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Randall E BrandDepartment of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID 0000-0002-4136-3313
University of Pittsburgh Medical Center · USKaiser Permanente · USUniversity of Pittsburgh · US

Funding

Validation of biomarkers for risk prediction and early diagnosis of Pancreatic AdenocarcinomaU01CA200466 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Surinder K. Batra, Randall Brand · 2016 to 2026
$11.3M
Detection of Pre-Invasive Pancreatic Cysts Using Protein and Glycan BiomarkersU01CA152653 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI ALLEN, PETER J, BRAND, RANDALL · 2010 to 2021
$5.8M
Digestive Diseases Training ProgramT32DK063922 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ARTEEL, GAVIN E, YADAV, DHIRAJ · 2003 to 2022
$5.2M
NCI NIH HHS U01 CA152653NCI NIH HHS U01 CA200466NIDDK NIH HHS T32 DK063922
6 · The paper itself

Abstract

backgroundAdolescent obesity is a national epidemic that recently has been shown to increase risk for pancreatic adenocarcinoma (PC) and is associated with an earlier age of PC onset. We hypothesized that PC patients who are overweight or obese at age 18 would have an earlier age of PC onset.

methodsRetrospective review of 531 patients in our PC registry was completed. Self-reported weight at age 18 and maximum lifetime weight were used to calculate body mass index (BMI) at age 18 (BMI-18) and maximum lifetime BMI.

resultsComplete BMI and baseline covariate data was available in 319 PC patients. Mean age (in years) of PC diagnosis for patients whose BMI-18 was overweight (64.0) or obese (59.9) was significantly different when compared to patients with a normal BMI-18 (66.7). No significant difference was observed in the mean age of PC diagnosis in those patients who maintained a normal BMI-18 when compared to those patients who subsequently became overweight or obese (67.0 versus 66.6;

conclusionsAn elevated BMI at age 18 is associated with an earlier age of PC onset and should be factored into determining the optimal age of beginning screening for patients at high risk for PC.

Identifiers

PMID29967636
PMCPMC6008748
OpenAlexW2806221181

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.