ArticleFrontiers in plant science2018
Cari p 1, a Novel Polygalacturonase Allergen From Papaya Acting as Respiratory and Food Sensitizer.
Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 27 citations in OpenAlex.
- Safety evaluation of the food enzyme endo-polygalacturonase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase and pectinesterase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme pectinesterase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing arabinan endo-1,5-α-l-arabinanase and endo-polygalacturonase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme bacillolysin from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme containing endo-polygalacturonase and pectinesterase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase, pectinesterase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme pectinesterase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex ofEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex ofEFSA journal. European Food Safety Authority · 2026Article
- Serological and biochemical characterization of Aspergillus fumigatus Asp f 10 as a potential diagnostic marker in ABPA and related respiratory diseases.Frontiers in allergy · 2026Article
- Safety evaluation of the food enzyme papain from the latex ofEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex ofEFSA journal. European Food Safety Authority · 2026Article
- Safety evaluation of the food enzyme endo-polygalacturonase from the genetically modifiedEFSA journal. European Food Safety Authority · 2025Article
- Monitoring, distribution and clinical relevance of airborne pollen and fern spores in Southeast Asia - A systematic review.The World Allergy Organization journal · 2025Review
- Safety evaluation of the food enzyme containing endo-polygalacturonase and β-glucosidase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2024Article
- Reported food-related symptoms and food allergen sensitization in a selected adult population in Hyderabad, India: A hospital-based survey.The journal of allergy and clinical immunology. Global · 2024Article
- Safety evaluation of the food enzyme endo-polygalacturonase from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2023Article
- Safety evaluation of a food enzyme containing endo-polygalacturonase and pectin lyase activities from the non-genetically modifiedEFSA journal. European Food Safety Authority · 2023Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Papaya has been reported to elicit IgE-mediated hypersensitivity via pollen inhalation and fruit consumption. Certain papaya sensitive patients with food allergy were found to experience recurrent respiratory distresses even after quitting the consumption of fruits. This observation prompted us to investigate the allergens commonly present in fruits and pollen grains of papaya. A discovery approach consisting of immunoproteomic detection followed by molecular characterization led to the identification of a novel papaya allergen designated as Cari p 1. This allergen was detected as a 56 kDa IgE-reactive protein from pollen as well as fruit proteome through serological analysis. The protein was identified as an endopolygalacturonase by tandem mass spectrometry. Full length Cari p 1 cDNA was isolated from papaya pollen, cloned in expression vector, and purified as recombinant allergen. The recombinant protein was monomeric and displayed pectinolytic activity. Recombinant Cari p 1 reacted with IgE-antibodies of all the papaya sensitized patient sera. In addition to IgE-reactivity, rCari p 1 displayed allergenic activity by stimulating histamine release from IgE-sensitized granulocytes. CD-spectroscopy of rCari p 1 revealed the presence of predominantly β-sheet characters. The melting curve of the allergen showed partial refolding from a fully denatured state indicating the possible presence of conformational IgE-epitopes characteristic of inhalant allergens in addition to the linear IgE-epitopes of food allergens. The expression of this allergen in papaya fruits was detected by immunoblot with anti-Cari p 1 rabbit IgG and reconfirmed by PCR. In an
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