Evidence map›Paper›PMID 29967615›Full record

ArticleFrontiers in immunology2018

The Microenvironment in Barrett's Esophagus Tissue Is Characterized by High

Alexandra Lind, Peter D Siersema, Johannes G Kusters, Tanja Konijn, Reina E Mebius, Leo Koenderman

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alexandra LindLaboratory of Translational Immunology, Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
Peter D SiersemaDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands.
Johannes G KustersDepartment of Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands.
Tanja KonijnDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands.
Reina E MebiusDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands.
Leo KoendermanLaboratory of Translational Immunology, Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
University Medical Center Utrecht · NLAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metaplasia in Barrett's esophagus (BE) is characterized by the transition of squamous epithelium into intestinal-type columnar epithelium. The immune response in BE shares many similarities with the response found in the gut, which is different from the response found in a normal-looking esophagus. Here, we investigated the role of the genes associated with the retinoic acid (RA) pathway in BE, as RA is important not only in shaping the gut's immune response but also in the induction of metaplasia

Indexed as

Barrett’s esophagusduodenumFOXP3RALDH2reflux esophagitisretinoic acid

Identifiers

PMID29967615
PMCPMC6015910
OpenAlexW2806829124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.