Evidence map›Paper›PMID 29967528›Full record

ArticlePediatric research2018

NKG2D gene variation and susceptibility to viral bronchiolitis in childhood.

Anu Pasanen, Minna K Karjalainen, Laura Kummola, Johannes Waage, Klaus Bønnelykke, Marja Ruotsalainen, Eija Piippo-Savolainen, Emma Goksör, Kirsi Nuolivirta, Bo Chawes and 8 more

Open access · bronzeAbstract read
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In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Genetic Susceptibility to Acute Viral Bronchiolitis.The Journal of infectious diseases · 2025
    Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 3 countries.

Anu PasanenPEDEGO Research Unit, Medical Research Center Oulu, and Department of Children and Adolescents, University of Oulu, Oulu University Hospital, Oulu, Finland. anu.pasanen@oulu.fi.
Minna K KarjalainenPEDEGO Research Unit, Medical Research Center Oulu, and Department of Children and Adolescents, University of Oulu, Oulu University Hospital, Oulu, Finland.
Laura KummolaFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Johannes WaageCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Klaus BønnelykkeCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Marja RuotsalainenDepartment of Pediatrics, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
Eija Piippo-SavolainenDepartment of Pediatrics, University of Eastern Finland, Kuopio University Hospital, Kuopio, Finland.
Emma GoksörDepartment of Pediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Kirsi NuolivirtaDepartment of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland.
Bo ChawesCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Nadja VissingCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Tuomas JarttiDepartment of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
Göran WennergrenDepartment of Pediatrics, University of Gothenburg, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Ilkka JunttilaFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Mikko HallmanPEDEGO Research Unit, Medical Research Center Oulu, and Department of Children and Adolescents, University of Oulu, Oulu University Hospital, Oulu, Finland.
Matti KorppiCenter for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland.
Mika RämetPEDEGO Research Unit, Medical Research Center Oulu, and Department of Children and Adolescents, University of Oulu, Oulu University Hospital, Oulu, Finland.
Tampere University · FICopenhagen Prospective Studies on Asthma in Childhood · DKUniversity of Eastern Finland · FIUniversity of Gothenburg · SEUniversity of Oulu · FIGentofte Hospital · DKOulu University Hospital · FISeinäjoki University of Applied Sciences · FITurku University Hospital · FIUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenetic factors associated with bronchiolitis are inadequately characterized. We therefore inspected a selected subpopulation of our previous genome-wide association study (GWAS) of bronchiolitis for overlap with known quantitative trait loci (QTLs) to identify susceptibility loci that potentially affect mRNA and protein levels.

methodsGWAS included a Finnish-Swedish case-control population (n = 187), matched for age and site. We integrated GWAS variants (p < 10

resultsBronchiolitis-susceptibility variant rs10772271 resided within QTLs previously associated with NKG2D (NK group 2, member D) mRNA and protein levels. Flow cytometric analysis confirmed the association with protein level in NK cells. The GWAS susceptibility allele (A) of rs10772271 (odds ratio [OR] = 2.34) corresponded with decreased NKG2D expression. The allele was nominally associated with bronchiolitis in one Finnish replicate (OR = 1.50), and the other showed directional consistency (OR = 1.43). No association was detected in Danish population

conclusionsThe bronchiolitis GWAS susceptibility allele was linked to decreased NKG2D expression in the QTL data and in our expression analysis. We propose that reduced NKG2D expression predisposes infants to severe bronchiolitis.

Indexed as

Genetic Predisposition to DiseaseAllelesBronchiolitis, ViralCase-Control StudiesChildChromosome MappingCohort StudiesDenmarkFemaleFinlandGenetic Association StudiesGenetic VariationGenome-Wide Association StudyGenotypeHaplotypesHumansKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily KRNA, Messenger

Identifiers

PMID29967528
OpenAlexW2806955511

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.