ArticleNature genetics2018
Adaptation and conservation insights from the koala genome.
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Article in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 2 pooled it
11.3field-weighted citation impact, top 1% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 283 citations in OpenAlex.
- Current status and future directions ofFrontiers in veterinary science · 2026Pooled it
- Pooled it
- Mutation rate estimate and population genomic analysis reveals decline of koalas prior to human arrival.Molecular biology and evolution · 2026Article
- Genetic Diversity Impacts Climate-Induced Species Range Shifts.Ecology letters · 2026Review
- Hyper-specialized primates possess a reduced suite of xenobiotic-metabolizing cytochrome P450 genes.Molecular phylogenetics and evolution · 2026Article
- Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.Genome biology and evolution · 2026Article
- Multi-generational koala pedigree analysis reveals rapid changes in heritable provirus load associated with life history traits.Nature communications · 2026Article
- Specialized Feeding Behavior of an Endangered Primate Enhances Forest Health in China.Ecology and evolution · 2026Article
- Koala Conservation: The Utility of Art and Genome Banking.Advances in experimental medicine and biology · 2026Review
- Age-dependent patterns of the gut microbiome, antibiotic resistome, and pathogenicity in captive koalas (Phascolarctos cinereus).Communications biology · 2025Article
- Development and Validation of a Standardised Genomic Tool for Conservation Management of the Koala (Animals : an open access journal from MDPI · 2025Article
- Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus.Viruses · 2025Article
- Conservation Arks: Genomic Erosion and Inbreeding in an Abundant Island Population of Koalas.Molecular ecology · 2025Article
- Exposure and hormone associations of pesticides and flame retardants among primates in Uganda.Environmental toxicology and chemistry · 2025Article
- A Guide for Developing Demo-Genetic Models to Simulate Genetic Rescue.Evolutionary applications · 2025Article
- Cathelicidin antimicrobial peptides mediate immune protection in marsupial neonates.Science advances · 2025Article
- Centromeric transposable elements and epigenetic status drive karyotypic variation in the eastern hoolock gibbon.Cell genomics · 2025Article
- Road to Extinction? Past and Present Population Structure and Genomic Diversity in the Koala.Molecular biology and evolution · 2025Article
- Phylogeny and Molecular Characterisation ofBrain sciences · 2025Article
- New insights into the range and transmission dynamics of a koala gammaherpesvirus, phascolarctid gammaherpesvirus 2.Scientific reports · 2025Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
54 authors at 17 institutions in 6 countries.
Rebecca N JohnsonAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia. rebecca.johnson@austmus.gov.au.ORCID http://orcid.org/0000-0003-3035-2827
Denis O'MeallySchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Zhiliang ChenSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
Graham J EtheringtonEarlham Institute, Norwich Research Park, Norwich, UK.
Simon Y W HoSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0361-2307
Will J NashEarlham Institute, Norwich Research Park, Norwich, UK.
Catherine E GrueberSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-8179-1822
Yuanyuan ChengSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Camilla M WhittingtonSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Siobhan DennisonAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Emma PeelSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Wilfried HaertyEarlham Institute, Norwich Research Park, Norwich, UK.
Rachel J O'NeillDepartment of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Don ColganAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Tonia L RussellRamaciotti Centre for Genomics, University of New South Wales, Kensington, New South Wales, Australia.
David E Alquezar-PlanasAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Val AttenbrowAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Jason G BraggResearch School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
Parice A BrandiesSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Amanda Yoon-Yee ChongEarlham Institute, Norwich Research Park, Norwich, UK.
Janine E DeakinInstitute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory, Australia.
Federica Di PalmaEarlham Institute, Norwich Research Park, Norwich, UK.
Zachary DudaDepartment of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Mark D B EldridgeAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Kyle M EwartAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Carolyn J HoggSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Greta J FrankhamAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Arthur GeorgesInstitute for Applied Ecology, University of Canberra, Bruce, Australian Capital Territory, Australia.
Amber K GillettAustralia Zoo Wildlife Hospital, Beerwah, Queensland, Australia.
Merran GovendirSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Alex D GreenwoodDepartment of Wildlife Diseases, Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany.
Takashi HayakawaDepartment of Wildlife Science (Nagoya Railroad Co., Ltd.), Primate Research Institute, Kyoto University, Inuyama, Japan.
Kristofer M HelgenAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Matthew HobbsAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6879-1369
Clare E HolleleyAustralian National Wildlife Collection, National Research Collections Australia, CSIRO, Canberra, Australian Capital Territory, Australia.
Thomas N HeiderDepartment of Molecular and Cell Biology and Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Elizabeth A JonesSydney School of Veterinary Science, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
Andrew KingAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Danielle MaddenAnimal Research Centre, Faculty of Science, Health, Education & Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
Jennifer A Marshall GravesResearch School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
Katrina M MorrisThe Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush, Midlothian, UK.
Linda E NeavesAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-5626-1029
Hardip R PatelJohn Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory, Australia.
Adam PolkinghorneAnimal Research Centre, Faculty of Science, Health, Education & Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
Marilyn B RenfreeSchool of BioSciences, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-4589-0436
Charles RobinSchool of BioSciences, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-7733-6763
Ryan SalinasSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
Kyriakos TsangarasDepartment of Translational Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
Paul D WatersSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
Shafagh A WatersSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
Belinda WrightAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Marc R WilkinsSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.
Peter TimmsFaculty of Science, Health, Education & Engineering, University of the Sunshine Coast, Maroochydore, Queensland, Australia.
Katherine BelovSchool of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, New South Wales, Australia.
The University of Sydney · AUAustralian Museum · AUUNSW Sydney · AUAustralian National University · AUNorwich Research Park · GBUniversity of Connecticut · USUniversity of the Sunshine Coast · AUThe University of Melbourne · AUUniversity of Canberra · AUAustralian National Wildlife Collection · AUAustralia Zoo · AUCentre for Human Genetics · GBCyprus Institute of Neurology and Genetics · CYKyoto University · JPLeibniz Institute for Zoo and Wildlife Research · DERoslin Institute · GBUniversity of East Anglia · GB
Funding
A singular opportunity to determine the evolutionary genetics of retroviral invasR01GM092706 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ROCA, ALFRED LUIS · 2011 to 2013
$849kBiotechnology and Biological Sciences Research Council BB/J004669/1Biotechnology and Biological Sciences Research Council BBS/E/T/000PR9817NIGMS NIH HHS R01 GM092706
Abstract
The koala, the only extant species of the marsupial family Phascolarctidae, is classified as 'vulnerable' due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala's ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala's survival in the wild.
Indexed as
Adaptation, PhysiologicalAnimalsAustraliaChlamydia InfectionsCytochrome P-450 Enzyme SystemFemaleGenomeMolecular Sequence AnnotationPhascolarctidaeTranslocation, GeneticCytochrome P-450 Enzyme System
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