ArticleNature medicine2018
Metformin reverses established lung fibrosis in a bleomycin model.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 320 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
320citing papers in PubMed, 2 pooled it
44.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
320 citing papers in PubMed, 2 syntheses or guidelines pooled it, 565 citations in OpenAlex.
- Pooled it
- Effectiveness and mechanism of metformin in animal models of pulmonary fibrosis: A preclinical systematic review and meta-analysis.Frontiers in pharmacology · 2022Pooled it
- DRTB-HDT: a randomized controlled trial of two adjunctive host-directed therapies in rifampin-resistant tuberculosis.BMC infectious diseases · 2025Trial
- Macrophage polarization plasticity in pulmonary fibrosis: a review from pathogenesis to therapeutic targeting.Inflammopharmacology · 2026Review
- Sinigrin Mitigates Pulmonary Inflammation and Fibrosis Partly through Adenosine Monophosphate-Activated Protein Kinase (AMPK) Signaling.ACS pharmacology & translational science · 2026Article
- Article
- Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Current perspectives on natural and pharmacological interventions for combating drug-induced pulmonary toxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- MRC2-mediated collagen internalization is reduced in fibrotic lung fibroblasts and increased upon phenotypic dedifferentiation.JCI insight · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Targeting the senescence‒autophagy axis via p16Signal transduction and targeted therapy · 2026Article
- Enhanced fatty acid availability rewires fibroblasts metabolism and decreases collagen deposition in lung fibrosis.Cellular and molecular life sciences : CMLS · 2026Article
- Hallmarks of the ageing lung: 10 years later.The European respiratory journal · 2026Review
- Article
- Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling.Cell reports. Medicine · 2026Article
- Pulmonary Fibrosis Beyond the Lung: Adipose Tissue as a Systemic Modifier of Fibrotic Remodeling.Diagnostics (Basel, Switzerland) · 2026Review
- Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution.Nature communications · 2026Article
- Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.Journal of advanced research · 2026Article
- Combined mesenchymal stem cells and metformin therapy modulates key macromolecular pathways in pulmonary fibrosis based on evidence from untargeted metabolomics.Scientific reports · 2026Article
- Deficiency of GCN5 exacerbates pulmonary fibrosis by disrupting the LKB1-AMPK pathway.Cell communication and signaling : CCS · 2026Article
260 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
14 authors at 3 institutions in 2 countries.
Sunad RangarajanDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-5313-4828
Nathaniel B BoneDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Anna A ZmijewskaDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Shaoning JiangDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-6445-9900
Dae Won ParkDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Karen BernardDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Morgan L LocyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-3812-5867
Saranya RaviDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessy DeshaneDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Roslyn B MannonDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-1776-3680
Edward AbrahamOffice of the Dean, School of Medicine, University of Miami, Miami, FL, USA.
Victor Darley-UsmarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Victor J ThannickalDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. vthannickal@uabmc.edu.
Jaroslaw W ZmijewskiDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. zmijewsk@uab.edu.ORCID http://orcid.org/0000-0001-7314-6164
University of Alabama at Birmingham · USKorea University · KRUniversity of Miami · US
Funding
Therapeutic Targeting of the Myofibroblast in Fibrotic Lung DiseaseP01HL114470 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2013 to 2022
$17.8MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MSex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DAVID B ALLISON · 2015 to 2026
$11.3MUAB Neuroscience Core CenterP30NS047466 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS · 2005 to 2019
$8.5MAMPK in the Development and Resolution of Lung FibrosisR01HL139617 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Victor J. Thannickal, Jaroslaw Waldemar Zmijewski · 2019 to 2026
$4.4MMyeloid-Derived Regulatory Cells in AsthmaR01HL128502 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DESHANE, JESSY SATYADAS · 2016 to 2020
$1.8MMyofibroblast Senescence in Pulmonary FibrosisR01AG046210 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THANNICKAL, VICTOR J. · 2014 to 2018
$1.6MAMPK activation and acute lung injuryR01HL107585 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZMIJEWSKI, JAROSLAW WALDEMAR · 2012 to 2015
$1.4MMitochondrial UCP2 in Age-Related Lung FibrosisK08HL135399 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI RANGARAJAN, SUNAD · 2017 to 2021
$841kProtein o,o'-Dityrosine Cross-linking in Lung Injury and Wound HealingF30HL136195 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCY, MORGAN LEE · 2017 to 2020
$141kAMP Kinase Activation in Calcineurin Inhibitor NephrotoxicityI01BX003272 · VA · OMAHA VA MEDICAL CENTER · PI MANNON, ROSLYN B · 2017 to 2021
–Sirtuins in Lung Aging and FibrosisI01BX003056 · VA · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · PI THANNICKAL, VICTOR J. · 2016 to 2025
–BLRD VA I01 BX003056BLRD VA I01 BX003272NHLBI NIH HHS F30 HL136195NHLBI NIH HHS K08 HL135399NHLBI NIH HHS P01 HL114470NHLBI NIH HHS R01 HL107585NHLBI NIH HHS R01 HL128502NHLBI NIH HHS R01 HL139617NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG046210NIGMS NIH HHS T32 GM008361NINDS NIH HHS P30 NS047466
Abstract
Fibrosis is a pathological result of a dysfunctional repair response to tissue injury and occurs in a number of organs, including the lungs
Indexed as
Adenylate KinaseAnimalsBleomycinDisease Models, AnimalEnzyme ActivationExtracellular Matrix ProteinsHumansIdiopathic Pulmonary FibrosisLungMaleMetforminMice, Inbred C57BLMitochondriaMyofibroblastsAdenylate KinaseBleomycinExtracellular Matrix ProteinsMetformin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.