Evidence map›Paper›PMID 29967329›Full record

ArticleNature communications2018

Synthetic molecular evolution of hybrid cell penetrating peptides.

W Berkeley Kauffman, Shantanu Guha, William C Wimley

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 96 citations in OpenAlex.

  1. Review
  2. Article
  3. Peeling back the layers of immunogenicity in Cas9-based genomic medicine.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
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  15. Review
  16. Article
  17. Article
  18. Block catiomers with flanking hydrolyzable tyrosinate groups enhanceScience and technology of advanced materials · 2023
    Article
  19. Article
  20. Designed Multifunctional Peptides for Intracellular Targets.Antibiotics (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

W Berkeley KauffmanDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
Shantanu GuhaDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA.
William C WimleyDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, USA. wwimley@tulane.edu.
Tulane University · US

Funding

Spontaneous Membrane Translocating PeptidesR01GM111824 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI WIMLEY, WILLIAM C · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM111824U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 5R01GM111824
6 · The paper itself

Abstract

Peptides and analogs such as peptide nucleic acids (PNA) are promising tools and therapeutics, but the cell membrane remains a barrier to intracellular targets. Conjugation to classical cell penetrating peptides (CPPs) such as pTat

Indexed as

Drug Delivery SystemsGain of Function MutationCell Membrane PermeabilityCell-Penetrating PeptidesDirected Molecular EvolutionFeasibility StudiesHeLa CellsHumansPeptide LibraryPeptide Nucleic AcidsPharmaceutical VehiclesRNA SplicingCell-Penetrating PeptidesPeptide LibraryPeptide Nucleic AcidsPharmaceutical Vehicles

Identifiers

PMID29967329
PMCPMC6028423
OpenAlexW2810229072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.