Evidence map›Paper›PMID 29967295›Full record

ArticleBioscience reports2018

APOL1 risk variants cause podocytes injury through enhancing endoplasmic reticulum stress.

Hongxiu Wen, Vinod Kumar, Xiqian Lan, Seyedeh Shadafarin Marashi Shoshtari, Judith M Eng, Xiaogang Zhou, Fang Wang, Haichao Wang, Karl Skorecki, Guolan Xing and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 61 citations in OpenAlex.

  1. Molecular Mechanisms of APOL1-Associated Kidney Disease.International journal of molecular sciences · 2026
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  19. Kidney medicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Hongxiu WenFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Vinod KumarFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Xiqian LanKey Laboratory for Aging and Regenerative Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China xlan@swmu.edu.cn psinghal@northwell.edu.
Seyedeh Shadafarin Marashi ShoshtariFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Judith M EngFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Xiaogang ZhouKey Laboratory for Aging and Regenerative Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Fang WangKey Laboratory for Aging and Regenerative Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Haichao WangFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Karl SkoreckiNephrology and Molecular Medicine, Technion Institute of Technology and Rambam Medical Center, Haifa, Israel.
Guolan XingDepartment of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou University Institute of Nephrology, Henan, China.
Guisheng WuKey Laboratory for Aging and Regenerative Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Huairong LuoKey Laboratory for Aging and Regenerative Medicine, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Ashwani MalhotraFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A.
Pravin C SinghalFeinstein Institute for Medical Research and Hofstra Northwell Medical School, Manhasset, NY, U.S.A. xlan@swmu.edu.cn psinghal@northwell.edu.
Southwest Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNTechnion – Israel Institute of Technology · IL

Funding

Mechanisms of Novel Herbal Therapies for Sepsis.R01AT005076 · NCCIH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI WANG, HAICHAO · 2010 to 2023
$4.3M
Regulation of HMGB1 Release in Endotoxemia.R01GM063075 · NIGMS · NORTH SHORE UNIVERSITY HOSPITAL · PI WANG, HAICHAO · 2002 to 2020
$4.2M
Epigenetic factors and HIV-associated NephropathyR01DK098074 · NIDDK · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SINGHAL, PRAVIN C · 2013 to 2016
$2.5M
Preclinical Development of a Novel Small Molecule Drug for SepsisR41GM123858 · NIGMS · THERASOURCE, LLC · PI BRENNER, MAX, WANG, HAICHAO · 2017 to 2018
$333k
NCCIH NIH HHS R01 AT005076NIDDK NIH HHS R01 DK098074NIGMS NIH HHS R01 GM063075NIGMS NIH HHS R41 GM123858
6 · The paper itself

Abstract

Two coding sequence variants (G1 and G2) of Apolipoprotein L1 (

Indexed as

Endoplasmic Reticulum StressAmino Acid SequenceApolipoprotein L1Base SequenceCell LineEndoplasmic Reticulum Chaperone BiPGenetic VariationHumansPodocytesRenal Insufficiency, ChronicAPOL1 protein, humanApolipoprotein L1Endoplasmic Reticulum Chaperone BiPHSPA5 protein, humanAPOL1ER stressPodocyte

Identifiers

PMID29967295
PMCPMC6131197
OpenAlexW2811098644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.