Evidence map›Paper›PMID 29967260›Full record

ArticleCancer research2018

Determination of Tumor Margins with Surgical Specimen Mapping Using Near-Infrared Fluorescence.

Rebecca W Gao, Nutte T Teraphongphom, Nynke S van den Berg, Brock A Martin, Nicholas J Oberhelman, Vasu Divi, Michael J Kaplan, Steven S Hong, Guolan Lu, Robert Ertsey and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Interim Phase II Results Using Panitumumab-IRDye800CW during Transoral Robotic Surgery in Patients with Oropharyngeal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Intraoperative fluorescence in solid head and neck cancer: A scoping review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rebecca W GaoStanford University School of Medicine, Stanford, California.
Nutte T TeraphongphomDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Nynke S van den BergDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Brock A MartinDepartment of Pathology, Stanford University, Stanford, California.
Nicholas J OberhelmanDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Vasu DiviDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Michael J KaplanDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Steven S HongDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Guolan LuDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Robert ErtseyDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Willemieke S F J TummersDepartment of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
Adam J GomezDepartment of Pathology, Stanford University, Stanford, California.
F Christopher HolsingerDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California.
Christina S KongDepartment of Pathology, Stanford University, Stanford, California.
Alexander D ColevasDepartment of Medicine, Division of Oncology, Stanford University, Stanford, California.
Jason M WarramDepartment of Otolaryngology, University of Alabama at Birmingham, Birmingham, Alabama.
Eben L RosenthalDepartment of Otolaryngology - Head and Neck Surgery, Stanford University, Stanford, California. elr@stanford.edu.

Funding

Research Training Program in Surgical OncologyT32CA091078 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KENNEDY, GREGORY DEAN · 2002 to 2017
$4.8M
Prototype optical device for image guided surgery with panitumumab-IRDye800R01CA190306 · NCI · STANFORD UNIVERSITY · PI ROSENTHAL, EBEN L. · 2015 to 2019
$2.6M
Imaging Guided Surgery using Fluorescently Labeled CetuximabR21CA182953 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARROLL, WILLIAM, WARRAM, JASON MORGAN · 2014 to 2015
$536k
Optical imaging of primary and regional melanoma to guide surgical resectionR21CA179171 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROSENTHAL, EBEN L. · 2013 to 2014
$347k
NCI NIH HHS R01 CA190306NCI NIH HHS R21 CA179171NCI NIH HHS R21 CA182953NCI NIH HHS T32 CA091078
6 · The paper itself

Abstract

For many solid tumors, surgical resection remains the gold standard and tumor-involved margins are associated with poor clinical outcomes. Near-infrared (NIR) fluorescence imaging using molecular agents has shown promise for

Indexed as

AdultAgedAged, 80 and overBiopsyCohort StudiesErbB ReceptorsFemaleFluorescenceGene Expression Regulation, NeoplasticHumansMaleMargins of ExcisionMiddle AgedOptical ImagingPanitumumabSpecimen HandlingEGFR protein, humanErbB ReceptorsPanitumumab

Identifiers

PMID29967260
PMCPMC6125224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.