Evidence map›Paper›PMID 29967223›Full record

ArticleEMBO reports2018

Notch-inducing hydrogels reveal a perivascular switch of mesenchymal stem cell fate.

Ulrich Blache, Queralt Vallmajo-Martin, Edward R Horton, Julien Guerrero, Valentin Djonov, Arnaud Scherberich, Janine T Erler, Ivan Martin, Jess G Snedeker, Vincent Milleret and 1 more

Abstract read
In one paragraph

Article in EMBO reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cell-extracellular matrix mechanotransduction in 3D.Nature reviews. Molecular cell biology · 2023
    Review
  8. Engineered hydrogels for mechanobiology.Nature reviews. Methods primers · 2022
    Article
  9. Review
  10. In Vitro and Ectopic In Vivo Studies toward the Utilization ofInternational journal of molecular sciences · 2022
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ulrich BlacheDepartment of Obstetrics, University Hospital of Zurich, Zurich, Switzerland.
Queralt Vallmajo-MartinDepartment of Obstetrics, University Hospital of Zurich, Zurich, Switzerland.
Edward R HortonBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Julien GuerreroDepartment of Biomedicine and Department of Surgery, University Hospital Basel, Basel, Switzerland.
Valentin DjonovInstitute of Anatomy, University of Bern, Bern, Switzerland.
Arnaud ScherberichDepartment of Biomedicine and Department of Surgery, University Hospital Basel, Basel, Switzerland.
Janine T ErlerBiotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark.
Ivan MartinDepartment of Biomedicine and Department of Surgery, University Hospital Basel, Basel, Switzerland.
Jess G SnedekerInstitute for Biomechanics, Eidgenössische Technische Hochschule (ETH) Zurich, Zurich, Switzerland.
Vincent MilleretDepartment of Obstetrics, University Hospital of Zurich, Zurich, Switzerland.
Martin EhrbarDepartment of Obstetrics, University Hospital of Zurich, Zurich, Switzerland martin.ehrbar@usz.ch.ORCID 0000-0003-2707-4870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fate of mesenchymal stem cells (MSCs) in the perivascular niche, as well as factors controlling their fate, is poorly understood. Here, we study MSCs in the perivascular microenvironment of endothelial capillaries by modifying a synthetic 3D biomimetic poly(ethylene glycol) (PEG)-hydrogel system

Indexed as

Cell LineageBone Marrow CellsCapillariesCellular MicroenvironmentCoculture TechniquesExtracellular MatrixHumansHuman Umbilical Vein Endothelial CellsHydrogelsMesenchymal Stem CellsNeovascularization, PhysiologicPolyethylene GlycolsReceptors, NotchHydrogelsPolyethylene GlycolsReceptors, Notchextracellular matrixmesenchymal stem cellNotch signalingperivascular nichesynthetic hydrogel

Identifiers

PMID29967223
PMCPMC6073216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.