ArticleProceedings of the National Academy of Sciences of the United States of America2018
Redundancy in synaptic connections enables neurons to learn optimally.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Predictive learning rules generate a cortical-like replay of probabilistic sensory experiences.eLife · 2025Article
- Article
- Parallel synapses with transmission nonlinearities enhance neuronal classification capacity.PLoS computational biology · 2025Article
- Reward integration in prefrontal-cortical and ventral-hippocampal nucleus accumbens inputs cooperatively modulates engagement.Nature communications · 2025Article
- Article
- Altered projection-specific synaptic remodeling and its modification by oxytocin in an idiopathic autism marmoset model.Communications biology · 2024Article
- Synchronization of delayed coupled neurons with multiple synaptic connections.Cognitive neurodynamics · 2024Article
- Short-term Hebbian learning can implement transformer-like attention.PLoS computational biology · 2024Article
- Model of the HVC neural network as a song motor in zebra finch.Frontiers in computational neuroscience · 2024Article
- Simulated synapse loss induces depression-like behaviors in deep reinforcement learning.Frontiers in computational neuroscience · 2024Article
- Neuron-targeted Knockout of APE1 Forces Premature Cognitive Impairment and Synaptic Dysfunction in Adult Mice.Aging and disease · 2022Article
- Drifting neuronal representations: Bug or feature?Biological cybernetics · 2022Review
- Emergence of synaptic organization and computation in dendrites.Neuroforum · 2022Review
- Maternal Cigarette Smoke Exposure Exaggerates the Behavioral Defects and Neuronal Loss Caused by Hypoxic-Ischemic Brain Injury in Female Offspring.Frontiers in cellular neuroscience · 2022Article
- Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder.Frontiers in neuroanatomy · 2022Article
- Role of NMDAR plasticity in a computational model of synaptic memory.Scientific reports · 2021Article
- Low-temperature emergent neuromorphic networks with correlated oxide devices.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Emergence of local and global synaptic organization on cortical dendrites.Nature communications · 2021Article
- Multiple synaptic connections into a single cortical pyramidal cell or interneuron in the anterior cingulate cortex of adult mice.Molecular brain · 2021Article
- The gradient clusteron: A model neuron that learns to solve classification tasks via dendritic nonlinearities, structural plasticity, and gradient descent.PLoS computational biology · 2021Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Recent experimental studies suggest that, in cortical microcircuits of the mammalian brain, the majority of neuron-to-neuron connections are realized by multiple synapses. However, it is not known whether such redundant synaptic connections provide any functional benefit. Here, we show that redundant synaptic connections enable near-optimal learning in cooperation with synaptic rewiring. By constructing a simple dendritic neuron model, we demonstrate that with multisynaptic connections synaptic plasticity approximates a sample-based Bayesian filtering algorithm known as particle filtering, and wiring plasticity implements its resampling process. Extending the proposed framework to a detailed single-neuron model of perceptual learning in the primary visual cortex, we show that the model accounts for many experimental observations. In particular, the proposed model reproduces the dendritic position dependence of spike-timing-dependent plasticity and the functional synaptic organization on the dendritic tree based on the stimulus selectivity of presynaptic neurons. Our study provides a conceptual framework for synaptic plasticity and rewiring.
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