Evidence map›Paper›PMID 29967174›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Chromatin organization by an interplay of loop extrusion and compartmental segregation.

Johannes Nuebler, Geoffrey Fudenberg, Maxim Imakaev, Nezar Abdennur, Leonid A Mirny

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 388 papers.

0numbers the graph read from it
0cells of the map it votes in
388citing papers in PubMed
37.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

388 citing papers in PubMed, 708 citations in OpenAlex.

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  15. A universal polymer signature in Hi-C resolves cohesin loop density and supports monomeric extrusion.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  17. Polycomb-mediated 3D chromatin interactions in gene regulation.Current opinion in genetics & development · 2026
    Review
  18. Article
  19. Article
  20. Article

328 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Johannes NueblerDepartment of Physics, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
Geoffrey FudenbergGladstone Institutes of Data Science and Biotechnology, San Francisco, CA 94158.ORCID 0000-0001-5905-6517
Maxim ImakaevDepartment of Physics, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
Nezar AbdennurDepartment of Physics, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139.
Leonid A MirnyDepartment of Physics, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139; leonid@mit.edu.ORCID 0000-0002-0785-5410
Massachusetts Institute of Technology · USGladstone Institutes · US

Funding

Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2015 to 2019
$14.9M
Spatio-Temporal Organization of Chromatin and Information Transfer in CancerU54CA193419 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MARKO, JOHN F · 2015 to 2020
$10.4M
Polymer models of mitotic and interphase chromosomesR01GM114190 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MIRNY, LEONID A · 2015 to 2023
$2.8M
NCI NIH HHS U54 CA193419NIDDK NIH HHS U54 DK107980NIGMS NIH HHS R01 GM114190
6 · The paper itself

Abstract

Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (

Indexed as

Models, BiologicalAnimalsCell Cycle ProteinsChromatinChromatin Assembly and DisassemblyChromosomal Proteins, Non-HistoneChromosomes, MammalianCohesinsCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsactive matterchromatingenome architectureHi-Cpolymer physics

Identifiers

PMID29967174
PMCPMC6055145
OpenAlexW2810076504

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.