Evidence map›Paper›PMID 29967172›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.

Inna Tabansky, Yupu Liang, Maya Frankfurt, Martin A Daniels, Matthew Harrigan, Sarah Stern, Teresa A Milner, Rebecca Leshan, Rrezarta Rama, Tabea Moll and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Inna TabanskyLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065; itabansky@rockefeller.edu Joel.n.h.stern@post.harvard.edu pfaff@rockefeller.edu.
Yupu LiangCenter for Clinical and Translational Science, The Rockefeller University, New York, NY 10065.
Maya FrankfurtLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065.
Martin A DanielsLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065.
Matthew HarriganCenter for Clinical and Translational Science, The Rockefeller University, New York, NY 10065.
Sarah SternLaboratory of Molecular Genetics, The Rockefeller University, New York, NY 10065.
Teresa A MilnerBrain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10065.
Rebecca LeshanLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065.
Rrezarta RamaLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065.
Tabea MollLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065.
Jeffrey M FriedmanLaboratory of Molecular Genetics, The Rockefeller University, New York, NY 10065.
Joel N H SternLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065; itabansky@rockefeller.edu Joel.n.h.stern@post.harvard.edu pfaff@rockefeller.edu.
Donald W PfaffLaboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065; itabansky@rockefeller.edu Joel.n.h.stern@post.harvard.edu pfaff@rockefeller.edu.
Rockefeller University · USCornell University · USHoward Hughes Medical Institute · US

Funding

Development and isolation of neurons that activate CNS arousal.F32HD081835 · NICHD · ROCKEFELLER UNIVERSITY · PI TABANSKY, INNA · 2015 to 2017
$185k
Howard Hughes Medical InstituteNICHD NIH HHS F32 HD081835
6 · The paper itself

Abstract

Neurons of the medullary reticular nucleus gigantocellularis (NGC) and their targets have recently been a focus of research on mechanisms supporting generalized CNS arousal (GA) required for proper cognitive functions. Using the retro-TRAP method, we characterized transcripts enriched in NGC neurons which have projections to the thalamus. The unique expression and activation of the endothelial nitric oxide (eNOS) signaling pathway in these cells and their intimate connections with blood vessels indicate that these neurons exert direct neurovascular coupling. Production of nitric oxide (NO) within eNOS-positive NGC neurons increases after environmental perturbations, indicating a role for eNOS/NO in modulating environmentally appropriate levels of GA. Inhibition of NO production causes dysregulated behavioral arousal after exposure to environmental perturbation. Further, our findings suggest interpretations for associations between psychiatric disorders and mutations in the eNOS locus.

Indexed as

BrainNitric Oxide Synthase Type IIIAnimalsArousalCerebrovascular CirculationGenetic LociMiceMice, TransgenicNeuronsSignal TransductionNitric Oxide Synthase Type IIINos3 protein, mousearousalendothelial nitric oxide synthasenucleus gigantocellularisreticular formationthalamus

Identifiers

PMID29967172
PMCPMC6055192
OpenAlexW2810730819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.