ArticleProceedings of the National Academy of Sciences of the United States of America2018
Backbone-free duplex-stacked monomer nucleic acids exhibiting Watson-Crick selectivity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- High-Yield Prebiotic Polymerization of 2',3'-Cyclic Nucleotides under Wet-Dry Cycling.ACS central science · 2025Article
- A twist grain boundary phase in aqueous solutions of the nucleic acid tetramer GTAC.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microfluidics-Based Drying-Wetting Cycles to Investigate Phase Transitions of Small Molecules Solutions.Life (Basel, Switzerland) · 2024Article
- Impact of Divalent Cations on In-Layer Positional Order of DNA-Based Liquid Crystals: Implications for DNA Condensation.Biomacromolecules · 2024Article
- Crystallization as a selection force at the polymerization of nucleotides in a prebiotic context.iScience · 2023Article
- Which came first: the chicken, the egg, or guanine?RNA (New York, N.Y.) · 2023Article
- Twisted Structures in Natural and Bioinspired Molecules: Self-Assembly and Propagation of Chirality Across Multiple Length Scales.ACS omega · 2023Review
- Non-enzymatic oligonucleotide ligation in coacervate protocells sustains compartment-content coupling.Nature communications · 2023Article
- Stability of End-to-End Base Stacking Interactions in Highly Concentrated DNA Solutions.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Hybridization kinetics of out-of-equilibrium mixtures of short RNA oligonucleotides.Nucleic acids research · 2022Article
- Quadruplex World.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
- Mono- and bilayer smectic liquid crystal ordering in dense solutions of "gapped" DNA duplexes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Driving forces in the origins of life.Open biology · 2021Article
- NMR analysis of nucleotide π-stacking in prebiotically relevant crowded environment.Communications chemistry · 2020Article
- Free energy of conformational isomers: The case of gapped DNA duplexes.The European physical journal. E, Soft matter · 2019Article
- Article
- Sticking and stacking: Persistent ordering of fragmented DNA analogs.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate that nucleic acid (NA) mononucleotide triphosphates (dNTPs and rNTPs), at sufficiently high concentration and low temperature in aqueous solution, can exhibit a phase transition in which chromonic columnar liquid crystal ordering spontaneously appears. Remarkably, this polymer-free state exhibits, in a self-assembly of NA monomers, the key structural elements of biological nucleic acids, including: long-ranged duplex stacking of base pairs, complementarity-dependent partitioning of molecules, and Watson-Crick selectivity, such that, among all solutions of adenosine, cytosine, guanine, and thymine NTPs and their binary mixtures, duplex columnar ordering is most stable in the A-T and C-G combinations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.