ArticleProceedings of the National Academy of Sciences of the United States of America2018
Subsystem organization of axonal connections within and between the right and left cerebral cortex and cerebral nuclei (endbrain).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed.
- Intrinsic neuronal network organization of a mammalian peripheral nervous system.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The intrinsic neuronal network of the central nervous system and its modular (subsystem) architecture in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Topographic organization of bidirectional connections between the cingulate region (infralimbic area and anterior cingulate area, dorsal part) and the interbrain (diencephalon) of the adult male rat.bioRxiv : the preprint server for biology · 2024Article
- Neural network architecture of a mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Network architecture of intrinsic connectivity in a mammalian spinal cord (the central nervous system's caudal sector).Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Intrinsic circuitry of the rhombicbrain (central nervous system's intermediate sector) in a mammal.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Connectomes: from a sparsity of networks to large-scale databases.Frontiers in neuroinformatics · 2023Review
- Structure-function subsystem model and computational lesions of the central nervous system's rostral sector (forebrain and midbrain).Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional connectivity of fMRI using differential covariance predicts structural connectivity and behavioral reaction times.Network neuroscience (Cambridge, Mass.) · 2022Article
- The brainstem connectome database.Scientific data · 2022Article
- The Connectome and Chemo-Connectome Databases for Mice Brain Connection Analysis.Frontiers in neuroanatomy · 2022Article
- Subsystem macroarchitecture of the intrinsic midbrain neural network and its tectal and tegmental subnetworks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regional, Layer, and Cell-Type-Specific Connectivity of the Mouse Default Mode Network.Neuron · 2021Article
- Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mapping the community structure of the rat cerebral cortex with weighted stochastic block modeling.Brain structure & function · 2020Article
- A model for mapping between the human and rodent cerebral cortex.The Journal of comparative neurology · 2019Article
- Article
- The network organization of rat intrathalamic macroconnections and a comparison with other forebrain divisions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Macroscale intrinsic network architecture of the hypothalamus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The endbrain (telencephalon) is at the rostral end of the central nervous system and is primarily responsible for supporting cognition and affect. Structurally, it consists of right and left cerebral hemispheres, each parceled into multiple cortical and nuclear gray matter regions. The global network organization of axonal macroconnections between the 244 regions forming the endbrain was analyzed with a multiresolution consensus clustering (MRCC) method that provides a hierarchical description of community clustering (modules or subsystems) within the network. Experimental evidence was collated from the neuroanatomical literature for the existence of 10,002 of a possible 59,292 connections within the network, and they cluster into four top-level subsystems and 60 bottom-level subsystems arranged in a 50-level hierarchy. Two top-level subsystems are bihemispheric: One deals with auditory and visual information, and the other corresponds broadly to the default mode network. The other two top-level subsystems are bilaterally symmetrical, and each deals broadly with somatic and visceral information. Because the entire endbrain connection matrix was assembled from multiple subconnectomes, it was easy to show that the status of a region as a connectivity hub is not absolute but, instead, depends on the size and coverage of its anatomical neighborhood. It was also shown numerically that creating an ultradense connection matrix by converting all "absent" connections to a "very weak" connection weight has virtually no effect on the clustering hierarchy. The next logical step in this project is to complete the forebrain connectome by adding the thalamus and hypothalamus (together, the interbrain) to the endbrain analysis.
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