ArticleProceedings of the National Academy of Sciences of the United States of America2018
Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- A rapid evidence assessment of the potential risk to the environment presented by active ingredients in the UK's most commonly sold companion animal parasiticides.Environmental science and pollution research international · 2022Pooled it
- In vitro and in vivo acaricidal properties of orally delivered ivermectin against the blacklegged tick, Ixodes scapularis.Parasites & vectors · 2026Article
- Discovery of mCMV280: An Oral Ectoparasiticide in the Isoxazoline Class with Reduced Mammalian Brain Exposure.Journal of medicinal chemistry · 2026Article
- Optimizing endectocide and ectocide compound evaluation in Anopheles malaria vectors.Parasites & vectors · 2025Article
- Comparative analysis of isoxazoline activity on human and canine GABA receptors expressed in Xenopus oocytes.Parasites & vectors · 2025Article
- Fluralaner treatment of chickens kills the southern house mosquito, Culex quinquefasciatus.Medical and veterinary entomology · 2025Article
- The mosquitocidal activity of isoxazoline derivatives afoxolaner, lotilaner, and fluralaner are not affected by mosquito sugar or antibiotic treatment.Scientific reports · 2025Article
- Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.Pest management science · 2025Article
- Nationwide cross-sectional surveillance of Leishmania donovani in phlebotomine sand flies and its impact on national kala-azar elimination in India.Scientific reports · 2024Article
- Fipronil prevents transmission of Lyme disease spirochetes.Parasitology · 2024Article
- Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control.Scientific reports · 2024Article
- Bluetongue Virus Infection in Farm Dogs Exposed to an Infected Sheep Flock in South Africa.Transboundary and emerging diseases · 2024Article
- Effect of fluralaner on the biology, survival, and reproductive fitness of the neotropical malaria vector Anopheles aquasalis.Malaria journal · 2023Article
- Evaluation of the scabicidal effect of a single dose of fluralaner in a rabbit model of crusted scabies.Parasitology research · 2023Article
- Antimalarial drug discovery: progress and approaches.Nature reviews. Drug discovery · 2023Review
- Topical, contact, and oral susceptibility of adult Culicoides biting midges (Diptera: Ceratopogonidae) to fluralaner.Parasites & vectors · 2023Article
- Fluralaner (BravectoParasites & vectors · 2023Article
- Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms.Parasites & vectors · 2022Article
- Survival and Fecundity of Anopheles stephensi and Anopheles albimanus Mosquitoes (Diptera: Culicidae) After Ingesting Bovine Blood Containing Various Veterinary Systemic Parasiticides.Journal of medical entomology · 2022Article
- Treatment of dogs with fluralaner reduced pyrethroid-resistant Triatoma infestans abundance, Trypanosoma cruzi infection and human-triatomine contact in the Argentine Chaco.Parasites & vectors · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 4 countries.
Funding
Abstract
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner rapidly killed
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.