Evidence map›Paper›PMID 29967150›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Distinct ways of G:U recognition by conserved tRNA binding motifs.

Yeeting E Chong, Min Guo, Xiang-Lei Yang, Bernhard Kuhle, Masahiro Naganuma, Shun-Ichi Sekine, Shigeyuki Yokoyama, Paul Schimmel

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  9. Article
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  11. Article
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  13. Article
  14. Aminoacyl-tRNA synthetases.RNA (New York, N.Y.) · 2020
    Review
  15. Article
  16. Article
  17. Information theory unveils the evolution of tRNA identity elements in the three domains of life.Theory in biosciences = Theorie in den Biowissenschaften · 2020
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yeeting E ChongThe Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
Min GuoDepartment of Molecular Medicine, The Scripps Florida Research Institute, Jupiter, FL 33458.
Xiang-Lei YangDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
Bernhard KuhleThe Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037.
Masahiro NaganumaDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, 113-0033 Tokyo, Japan.
Shun-Ichi SekineDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, 113-0033 Tokyo, Japan.ORCID 0000-0001-8174-8704
Shigeyuki YokoyamaDepartment of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, 113-0033 Tokyo, Japan.ORCID 0000-0003-3133-7338
Paul SchimmelThe Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037; schimmel@scripps.edu.
Scripps Research Institute · USSystems Biology Institute · JP

Funding

INVESTIGATIONS OF REACTIONS OF PHYSIOLOGICAL IMPORTANCER01GM015539 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHIMMEL, PAUL R · 1985 to 2011
$6.6M
GENETIC APPROACHES TO PROTEIN/NUCLEIC ACID INTERACTIONSR01GM023562 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHIMMEL, PAUL R · 1985 to 2012
$4.9M
NIGMS NIH HHS R01 GM015539NIGMS NIH HHS R01 GM023562
6 · The paper itself

Abstract

Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNA

Indexed as

Models, MolecularNucleotide MotifsAlanine-tRNA LigaseEscherichia coliEscherichia coli ProteinsHumansMutationRNA, TransferAlanine-tRNA LigaseEscherichia coli ProteinsRNA, Transferaminoacyl-tRNA synthetaseevolutionsecond genetic codespecificitytRNA

Identifiers

PMID29967150
PMCPMC6055181
OpenAlexW2810772875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.