ArticleProceedings of the National Academy of Sciences of the United States of America2018
Confinement generates single-crystal aragonite rods at room temperature.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 86 citations in OpenAlex.
- A Novel Approach Endowing Nanocalcium Carbonate with Amphiphobic Properties Through Perfluoropolyether Carboxylic Acid Surface Modification: Elucidating the Surface Modification Mechanism.Molecules (Basel, Switzerland) · 2026Article
- The Role of Confinement in Biomineralization.Chemical reviews · 2025Review
- Nanostructured Surfaces Enhance Nucleation Rate of Calcium Carbonate.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Light-driven nucleation, growth, and patterning of biorelevant crystals using resonant near-infrared laser heating.Nature communications · 2023Article
- Insights into the precipitation kinetics of CaCOJournal of applied crystallography · 2023Article
- Electron transparent nanotubes reveal crystallization pathways in confinement.Chemical science · 2023Article
- EdiacaraniScience · 2022Article
- Polyamines Promote Aragonite Nucleation and Generate Biomimetic Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Nested Formation of Calcium Carbonate Polymorphs in a Bacterial Surface Membrane with a Graded Nanoconfinement: An Evolutionary Strategy to Ensure Bacterial Survival.ACS biomaterials science & engineering · 2022Article
- Intracellular nanoscale architecture as a master regulator of calcium carbonate crystallization in marine microalgae.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Topographically guided hierarchical mineralization.Materials today. Bio · 2021Article
- Analysis of complex, beam-sensitive materials by transmission electron microscopy and associated techniques.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Ps19, a novel chitin binding protein from Pteria sterna capable to mineralize aragonite plates in vitro.PloS one · 2020Article
- Droplet-basedRSC advances · 2019Article
- Nucleation in confinement generates long-range repulsion between rough calcite surfaces.Scientific reports · 2019Article
- Aragonite formation in confinements: A step toward understanding polymorph control.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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8 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The topic of calcite and aragonite polymorphism attracts enormous interest from fields including biomineralization and paleogeochemistry. While aragonite is only slightly less thermodynamically stable than calcite under ambient conditions, it typically only forms as a minor product in additive-free solutions at room temperature. However, aragonite is an abundant biomineral, and certain organisms can selectively generate calcite and aragonite. This fascinating behavior has been the focus of decades of research, where this has been driven by a search for specific organic macromolecules that can generate these polymorphs. However, despite these efforts, we still have a poor understanding of how organisms achieve such selectivity. In this work, we consider an alternative possibility and explore whether the confined volumes in which all biomineralization occurs could also influence polymorph. Calcium carbonate was precipitated within the cylindrical pores of track-etched membranes, where these enabled us to systematically investigate the relationship between the membrane pore diameter and polymorph formation. Aragonite was obtained in increasing quantities as the pore size was reduced, such that oriented single crystals of aragonite were the sole product from additive-free solutions in 25-nm pores and significant quantities of aragonite formed in pores as large as 200 nm in the presence of low concentrations of magnesium and sulfate ions. This effect can be attributed to the effect of the pore size on the ion distribution, which becomes of increasing importance in small pores. These intriguing results suggest that organisms may exploit confinement effects to gain control over crystal polymorph.
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