Evidence map›Paper›PMID 29967119›Full record

ReviewJournal of bacteriology2018

After the Fact(or): Posttranscriptional Gene Regulation in Enterohemorrhagic Escherichia coli O157:H7.

Amber B Sauder, Melissa M Kendall

Abstract readReview
In one paragraph

Review in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. ThemSphere · 2024
    Article
  4. Article
  5. Microbiology (Reading, England) · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Amber B SauderDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Melissa M KendallDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA melissakendall@virginia.edu.

Funding

Global Biothreats Training ProgramT32AI055432 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI CRISS, ALISON K, PETRI, WILLIAM A · 2003 to 2022
$4.0M
Ethanolamine Signaling in Virulence Gene Regulation and Host/Microbial InteractionsR01AI118732 · NIAID · UNIVERSITY OF VIRGINIA · PI KENDALL, MELISSA · 2015 to 2019
$1.9M
Mechanisms involved in Salmonella immune evasionR21AI130439 · NIAID · UNIVERSITY OF VIRGINIA · PI KENDALL, MELISSA · 2018 to 2019
$437k
NIAID NIH HHS R01 AI118732NIAID NIH HHS R21 AI130439NIAID NIH HHS T32 AI055432
6 · The paper itself

Abstract

To adapt to ever-changing environments, pathogens quickly alter gene expression. This can occur through transcriptional, posttranscriptional, or posttranslational regulation. Historically, transcriptional regulation has been thoroughly studied to understand pathogen niche adaptation, whereas posttranscriptional and posttranslational gene regulation has only relatively recently been appreciated to play a central role in bacterial pathogenesis. Posttranscriptional regulation may involve chaperones, nucleases, and/or noncoding small RNAs (sRNAs) and typically controls gene expression by altering the stability and/or translation of the target mRNA. In this review, we highlight the global importance of posttranscriptional regulation to enterohemorrhagic

Indexed as

Gene Expression Regulation, BacterialRNA Processing, Post-TranscriptionalAnimalsDisease Models, AnimalEnterohemorrhagic Escherichia coliHumansIntestinesRNA, Small UntranslatedVirulenceVirulence FactorsRNA, Small UntranslatedVirulence FactorsEHECenterohemorrhagic E. colipathogenesisposttranscriptional regulationregulation of gene expressionsRNAvirulence

Identifiers

PMID29967119
PMCPMC6148468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.