Evidence map›Paper›PMID 29967100›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

miR-155 Modulates Cockroach Allergen- and Oxidative Stress-Induced Cyclooxygenase-2 in Asthma.

Lipeng Qiu, Yan Zhang, Danh C Do, Xia Ke, Simin Zhang, Kristin Lambert, Shruthi Kumar, Chengping Hu, Yufeng Zhou, Faoud T Ishmael and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

  1. Role of miR-155 in inflammatory autoimmune diseases: a comprehensive review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Pooled it
  2. Circulating MicroRNAs and Treatment Response in Childhood Asthma.American journal of respiratory and critical care medicine · 2020
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. ATP functions as a primary alarmin in allergen-induced type 2 immunity.American journal of physiology. Cell physiology · 2023
    Review
  14. Exploration of the Molecular Mechanisms ofBioMed research international · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Lipeng QiuDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.ORCID 0000-0003-4382-0976
Yan ZhangDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.ORCID 0000-0001-6427-7517
Danh C DoDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.ORCID 0000-0002-1065-7140
Xia KeDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
Simin ZhangDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA 17033; and.ORCID 0000-0002-9128-2095
Kristin LambertDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA 17033; and.
Shruthi KumarDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.ORCID 0000-0002-2954-9991
Chengping HuDepartment of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Yufeng ZhouChildren's Hospital and Institute of Biomedical Sciences, Fudan University, Key Laboratory of Neonatal Diseases, Ministry of Health, Shanghai 201102, China.
Faoud T IshmaelDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Pennsylvania State University Milton S. Hershey Medical Center, Hershey, PA 17033; and pgao1@jhmi.edu fishmael@hmc.psu.edu.
Peisong GaoDivision of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224; pgao1@jhmi.edu fishmael@hmc.psu.edu.ORCID 0000-0002-7651-1339
Johns Hopkins University · USPennsylvania State University · USCentral South University · CNFudan University · CNJiangsu University · CN

Funding

Sensitization to Cockroach Allergen: Immune Regulation and Genetic DeterminantsR01ES021739 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2013 to 2017
$1.8M
Mannose Receptor, miR-511-3p, and Macrophage Polarization in AsthmaR21AI121768 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2016 to 2017
$462k
Lineage Commitment of Mesenchymal Stem Cell in Allergen-induced Airway RemodelingR21AI109062 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GAO, PEISONG · 2014 to 2015
$446k
NIAID NIH HHS R21 AI109062NIAID NIH HHS R21 AI121768NIEHS NIH HHS R01 ES021739
6 · The paper itself

Abstract

Exposure to cockroach allergen is a strong risk factor for developing asthma. Asthma has been associated with allergen-induced airway epithelial damage and heightened oxidant stress. In this study, we investigated cockroach allergen-induced oxidative stress in airway epithelium and its underlying mechanisms. We found that cockroach extract (CRE) could induce reactive oxygen species (ROS) production, particularly mitochondrial-derived ROS, in human bronchial epithelial cells. We then used the RT

Indexed as

AllergensAnimalsAsthmaBronchiBronchoalveolar Lavage FluidCells, CulturedCockroachesCyclooxygenase 2CytokinesEpithelial CellsHumansLungMiceMice, Inbred C57BLMice, KnockoutMicroRNAsAllergensCyclooxygenase 2CytokinesMicroRNAsMirn155 microRNA, mouseReactive Oxygen Species

Identifiers

PMID29967100
PMCPMC6057819
OpenAlexW2810698917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.