Evidence map›Paper›PMID 29966581›Full record

ArticleBMB reports2018

Exosomes derived from microRNA-584 transfected mesenchymal stem cells: novel alternative therapeutic vehicles for cancer therapy.

Ran Kim, Seokyeon Lee, Jihyun Lee, Minji Kim, Won Jung Kim, Hee Won Lee, Min Young Lee, Jongmin Kim, Woochul Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

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  18. Exosomes as Novel Diagnostic Biomarkers and Therapeutic Tools in Gliomas.International journal of molecular sciences · 2023
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Ran KimDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Seokyeon LeeDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Jihyun LeeDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Minji KimDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Won Jung KimDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Hee Won LeeDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Min Young LeeDepartment of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 41566, Korea.
Jongmin KimDepartment of Life Systems, Sookmyung Women's University, Seoul 04310, Korea.
Woochul ChangDepartment of Biology Education, College of Education, Pusan National University, Busan 46241, Korea.
Pusan National University · KRKyungpook National University · KRSookmyung Women's University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small membranous vesicles which contain abundant RNA molecules, and are transferred from releasing cells to uptaking cells. MicroRNA (miRNA) is one of the transferred molecules affecting the adopted cells, including glioma cells. We hypothesized that mesenchymal stem cells (MSCs) can secrete exosomes loading miRNA and have important effects on the progress of gliomas. To determine these effects by treating exosomal miRNA in culture media of miRNA mimic transfected MSCs, we assessed the in vitro cell proliferation and invasion capabilities, and the expression level of relative proteins associated with cell apoptosis, growth and migration. For animal studies, the mice injected with U87 cells were exposed to exosomes derived from miRNA-584-5p transfected MSCs, to confirm the influence of exosomal miRNA on the progress of glioma. Based on our results, we propose a new targeted cancer therapy wherein exosomes derived from miRNA transfected MSCs could be used to modulate tumor progress as the anticancer vehicles. [BMB Reports 2018; 51(8): 406-411].

Indexed as

AnimalsBrain NeoplasmsCell Line, TumorCell ProliferationExosomesGliomaHumansMesenchymal Stem CellsMiceMice, NudeMicroRNAsTransfectionMicroRNAsMIRN584 microRNA, human

Identifiers

PMID29966581
PMCPMC6130835
OpenAlexW2889433138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.